PMID- 27941912
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180522
LR  - 20210323
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Dec 12
TI  - Quantitative determination and toxicity evaluation of 2,4-dichlorophenol using 
      poly(eosin Y)/hydroxylated multi-walled carbon nanotubes modified electrode.
PG  - 38657
LID - 10.1038/srep38657 [doi]
LID - 38657
AB  - This study aimed at developing simple, sensitive and rapid electrochemical 
      approach to quantitatively determine and assess the toxicity of 
      2,4-dichlorophenol (2,4-DCP), a priority pollutant and has potential risk to 
      public health through a novel poly(eosin Y, EY)/hydroxylated multi-walled carbon 
      nanotubes composite modified electrode (PEY/MWNTs-OH/GCE). The distinct feature 
      of this easy-fabricated electrode was the synergistic coupling effect between EY 
      and MWNTs-OH that enabled a high electrocatalytic activity to 2,4-DCP. Under 
      optimum conditions, the oxidation peak current enhanced linearly with 
      concentration increasing from 0.005 to 0.1 muM and 0.2 to 40.0 muM, and revealed 
      the detection limit of 1.5 nM. Moreover, the PEY/MWNTs-OH/GCE exhibited excellent 
      electrocatalytic activity toward intracellular electroactive species. Two 
      sensitive electrochemical signals ascribed to guanine/xanthine and 
      adenine/hypoxanthine in human hepatoma (HepG2) cells were detected 
      simultaneously. The sensor was successfully applied to evaluate the toxicity of 
      2,4-DCP to HepG2 cells. The IC(50) values based on the two electrochemical 
      signals are 201.07 and 252.83 muM, respectively. This study established a 
      sensitive platform for the comprehensive evaluation of 2,4-DCP and posed a great 
      potential to simplify environmental toxicity monitoring.
FAU - Zhu, Xiaolin
AU  - Zhu X
AD  - School of Environment, Northeast Normal University, Changchun 130117, P.R. China.
FAU - Zhang, Kexin
AU  - Zhang K
AD  - School of Environment, Northeast Normal University, Changchun 130117, P.R. China.
FAU - Wang, Chengzhi
AU  - Wang C
AD  - School of Environment, Northeast Normal University, Changchun 130117, P.R. China.
FAU - Guan, Jiunian
AU  - Guan J
AD  - School of Environment, Northeast Normal University, Changchun 130117, P.R. China.
FAU - Yuan, Xing
AU  - Yuan X
AD  - School of Environment, Northeast Normal University, Changchun 130117, P.R. China.
FAU - Li, Baikun
AU  - Li B
AD  - Department of Civil and Environmental Engineering, University of Connecticut, 
      Storrs, CT 06269, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161212
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
EIN - Sci Rep. 2021 Mar 9;11(1):5864. PMID: 33750852
PMC - PMC5150580
EDAT- 2016/12/13 06:00
MHDA- 2016/12/13 06:01
PMCR- 2016/12/12
CRDT- 2016/12/13 06:00
PHST- 2016/09/07 00:00 [received]
PHST- 2016/11/10 00:00 [accepted]
PHST- 2016/12/13 06:00 [entrez]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2016/12/13 06:01 [medline]
PHST- 2016/12/12 00:00 [pmc-release]
AID - srep38657 [pii]
AID - 10.1038/srep38657 [doi]
PST - epublish
SO  - Sci Rep. 2016 Dec 12;6:38657. doi: 10.1038/srep38657.