PMID- 27942289
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1918-2805 (Print)
IS  - 1918-2813 (Electronic)
IS  - 1918-2805 (Linking)
VI  - 3
IP  - 3
DP  - 2010 Jun
TI  - Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of 
      Steroid-Dependent Ulcerative Colitis.
PG  - 120-124
AB  - BACKGROUND: This study was to investigate the pathological significance of 
      protein expression of matrix metalloproteinase-1 (MMP1) and matrix 
      metalloproteinase-3 (MMP3) in colon tissues of remission patients of 
      steroid-dependent uncreative colitis (SDUC). METHODS: To test the possible 
      involvement of MMP-1 and MMP-3 in SDUC, Western- blot and immunohistochemistry 
      were applied to examine the protein expression of MMP-1 and MMP-3 in the colonic 
      healing region from 10 remission patients with SDUC as well as from 10 remission 
      patients with non-SDUC. Ten specimens from normal colon tissues were used as 
      controls. RESULTS: Compared with the control group, the protein expression of 
      MMP-1 and MMP-3 from non-SDUC remission patients slightly increased (p > 0.05), 
      in contrast, those from SDUC patients significantly increased (p < 0.01). 
      CONCLUSIONS: Over-expression of MMP-1 and MMP-3 play a critical role in the 
      pathogenesis of SDUC.
FAU - Wang, Zhi Yong
AU  - Wang ZY
AD  - Department of Digestive Diseases, Affiliated Hospital of Hangzhou Normal 
      University (the Second People's Hospital of Hangzhou City), Hangzhou 310015, 
      Zhejiang Province, China.
FAU - Qiu, Bing Feng
AU  - Qiu BF
AD  - Department of Digestive Diseases, Affiliated Hospital of Hangzhou Normal 
      University (the Second People's Hospital of Hangzhou City), Hangzhou 310015, 
      Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20100520
PL  - Canada
TA  - Gastroenterology Res
JT  - Gastroenterology research
JID - 101519422
PMC - PMC5139765
OTO - NOTNLM
OT  - Metalloproteinase
OT  - Steroid-dependent
OT  - Ulcerative colitis
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
PMCR- 2010/06/01
CRDT- 2016/12/13 06:00
PHST- 2010/05/28 00:00 [accepted]
PHST- 2016/12/13 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 10.4021/gr2010.05.208w [doi]
PST - ppublish
SO  - Gastroenterology Res. 2010 Jun;3(3):120-124. doi: 10.4021/gr2010.05.208w. Epub 
      2010 May 20.