PMID- 27942499
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2251-9637 (Print)
IS  - 2251-9645 (Electronic)
IS  - 2251-9637 (Linking)
VI  - 5
IP  - 3
DP  - 2016 Summer
TI  - MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an 
      Iranian Population.
PG  - 134-140
AB  - Considering that MAPK (mitogen- activated protein kinase) signaling pathway has 
      an important role in the progression of inflammatory cytokine secretion in type 2 
      diabetes mellitus (T2DM), we have recently investigated the reported genetic 
      polymorphism from genome wide association study in MAP(3)K(1) (mitogen-activated 
      protein kinase kinase kinase 1) in diabetes as an important member of MAPK 
      signaling. This study aimed to investigate the possible association of rs10461617 
      at the upstream of MAP(3)K(1) gene in an Iranian case-control study with the risk 
      of T2DM. The study population was comprised of 342 unrelated Iranian individuals 
      including 177 patients with T2DM and 165 unrelated healthy control subjects. 
      Genotyping was performed using PCR-RFLP and confirmed with sequencing. In a 
      logistic regression analysis, the rs10461617A allele was associated with a 
      significantly higher risk of T2DM assuming the log- additive model (OR: 1.44, 95% 
      CI: 1.01-2.05, P = 0.039). In conclusion, we provided the first evidence for the 
      association of rs10461617 at the upstream of MAP(3)K(1) with the risk of T2DM in 
      an Iranian population.
FAU - Torkamandi, Shahram
AU  - Torkamandi S
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Bastami, Milad
AU  - Bastami M
AD  - Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Ghaedi, Hamid
AU  - Ghaedi H
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Moghadam, Fateme
AU  - Moghadam F
AD  - Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Mirfakhraie, Reza
AU  - Mirfakhraie R
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Omrani, Mir Davood
AU  - Omrani MD
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160821
PL  - Iran
TA  - Int J Mol Cell Med
JT  - International journal of molecular and cellular medicine
JID - 101598104
PMC - PMC5125365
OTO - NOTNLM
OT  - MAP3K1
OT  - Type 2 diabetes mellitus
OT  - cytokines
OT  - genome- wide association study
EDAT- 2016/12/13 06:00
MHDA- 2016/12/13 06:01
PMCR- 2016/06/01
CRDT- 2016/12/13 06:00
PHST- 2016/06/01 00:00 [received]
PHST- 2016/07/02 00:00 [accepted]
PHST- 2016/12/13 06:00 [entrez]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2016/12/13 06:01 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - ijmcm-5-134 [pii]
PST - ppublish
SO  - Int J Mol Cell Med. 2016 Summer;5(3):134-140. Epub 2016 Aug 21.