PMID- 27943013
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20170328
IS  - 1572-9699 (Electronic)
IS  - 0003-6072 (Linking)
VI  - 110
IP  - 3
DP  - 2017 Mar
TI  - Further analysis reveals new gut microbiome markers of type 2 diabetes mellitus.
PG  - 445-453
LID - 10.1007/s10482-016-0805-3 [doi]
AB  - In recent years, metagenome-wide association studies have revealed potential 
      relationships between intestinal microbiomes and the pathogenesis of type 2 
      diabetes mellitus (T2DM). However, considering the increase in volume of gene 
      catalogues and algorithms, an updated analysis would be expected to confirm 
      previous discoveries and provide new knowledge. We therefore constructed new 
      profiles after mapping the recent catalogue of reference genes in the human gut 
      microbiome to reanalyze samples from T2DM cases and controls in the Chinese 
      population. We identified different compositions between Chinese controls and 
      T2DM patients at the species and genus levels, especially in the case of 
      butyrate-producing bacteria, Haemophilus, and Lactobacillus. An effective 
      metagenomic linkage group random forest model was built to differentiate controls 
      from T2DM cases in different cohorts. Functional markers from the Kyoto 
      Encyclopedia of Genes and Genomes database were identified using new annotations. 
      We also report 16 virulence factor markers and 22 antibiotic resistance markers 
      associated with T2DM.
FAU - Wang, Xiaokai
AU  - Wang X
AD  - BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China. 
      viruswater@hotmail.com.
AD  - BGI-Shenzhen, Shenzhen, 518083, China. viruswater@hotmail.com.
FAU - Xu, Xiaoqiang
AU  - Xu X
AD  - BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
AD  - BGI-Shenzhen, Shenzhen, 518083, China.
FAU - Xia, Yan
AU  - Xia Y
AD  - BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
AD  - BGI-Shenzhen, Shenzhen, 518083, China.
LA  - eng
PT  - Journal Article
DEP - 20161210
PL  - Netherlands
TA  - Antonie Van Leeuwenhoek
JT  - Antonie van Leeuwenhoek
JID - 0372625
RN  - 0 (Genetic Markers)
SB  - IM
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*microbiology
MH  - Feces/microbiology
MH  - Gastrointestinal Microbiome/*genetics
MH  - Genetic Markers/genetics
MH  - Genome, Microbial
MH  - Humans
MH  - Metagenome
MH  - Metagenomics/methods
OTO - NOTNLM
OT  - Antibiotic resistance
OT  - Gut microbiome
OT  - Metagenome
OT  - T2DM
OT  - Virulence factor
EDAT- 2016/12/13 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/12/13 06:00
PHST- 2016/08/06 00:00 [received]
PHST- 2016/11/15 00:00 [accepted]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PHST- 2016/12/13 06:00 [entrez]
AID - 10.1007/s10482-016-0805-3 [pii]
AID - 10.1007/s10482-016-0805-3 [doi]
PST - ppublish
SO  - Antonie Van Leeuwenhoek. 2017 Mar;110(3):445-453. doi: 10.1007/s10482-016-0805-3. 
      Epub 2016 Dec 10.