PMID- 2794921
OWN - NLM
STAT- MEDLINE
DCOM- 19891107
LR  - 20150901
IS  - 0371-7682 (Print)
IS  - 0371-7682 (Linking)
VI  - 88
IP  - 3
DP  - 1989 Mar
TI  - Erythrocyte deformability in diabetes mellitus.
PG  - 240-3
AB  - Erythrocyte filterability was measured on 34 diabetic patients and 43 normal 
      subjects. Filterability index (FI) was expressed as FI = 10 x ratio of flow rate 
      of suspension to buffer. Mean FI (mean +/- SE) of diabetics was significantly 
      lower than that of the control group (3.47 +/- 0.09 vs 4.03 +/- 0.07, p less than 
      0.0001). Values of blood urea nitrogen, triglycerides, fasting and postprandial 
      plasma glucose, HbAlc, white blood cell counts (WBC), and mean corpuscular 
      hemoglobin concentration (MCHC) were higher in diabetics. However, mean 
      corpuscular volume (MCV) of diabetics was lower than that of the control group 
      (90.1 +/- 0.6 vs 93.4 +/- 0.6 fl, p less than 0.001), and MCV was positively 
      correlated with FI in both groups. Blood urea nitrogen, triglycerides, fasting 
      and postprandial plasma glucose, HbAlc, MCHC, WBC were correlated inversely with 
      FI. Multiple linear regression analysis revealed FI = -0.00266 (fasting plasma 
      glucose) -0.00164 (triglyceride) -0.00041 (blood urea nitrogen) +5.07 (n = 77, R 
      = 0.61, p less than 0.05). Diabetic patients with cardiovascular complications 
      had lower FI and MCV values; however they had higher triglyceride values than 
      those without cardiovascular complications. In summary, RBC filterability of 
      diabetic patients was lower than that of normal subjects. The defect could be due 
      to myriads of metabolic derangement.
FAU - Wu, T J
AU  - Wu TJ
FAU - Chuang, L M
AU  - Chuang LM
FAU - Tai, T Y
AU  - Tai TY
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Taiwan Yi Xue Hui Za Zhi
JT  - Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association
JID - 0413761
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Cerebral Infarction/complications
MH  - Diabetes Complications
MH  - Diabetes Mellitus/*blood
MH  - *Erythrocyte Deformability
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications
MH  - Triglycerides/blood
MH  - Vascular Diseases/complications
EDAT- 1989/03/01 00:00
MHDA- 1989/03/01 00:01
CRDT- 1989/03/01 00:00
PHST- 1989/03/01 00:00 [pubmed]
PHST- 1989/03/01 00:01 [medline]
PHST- 1989/03/01 00:00 [entrez]
PST - ppublish
SO  - Taiwan Yi Xue Hui Za Zhi. 1989 Mar;88(3):240-3.