PMID- 27951592
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20220311
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 15
DP  - 2016 Dec 1
TI  - Novel Bruch's Membrane Opening Minimum Rim Area Equalizes Disc Size Dependency 
      and Offers High Diagnostic Power for Glaucoma.
PG  - 6596-6603
LID - 10.1167/iovs.16-20561 [doi]
AB  - PURPOSE: The purpose of this study was to assess the diagnostic power of the 
      novel two-dimensional parameter Bruch's membrane opening minimal rim area 
      (BMO-MRA) in spectral-domain optical coherence tomography (SD-OCT) for detection 
      of glaucoma compared to minimal rim width (BMO-MRW) and retinal nerve fiber layer 
      (RNFL) thickness in large and small optic discs. METHODS: In this case-control, 
      cross-sectional study, 207 eyes of 207 participants, including 89 controls and 97 
      patients with glaucoma and 21 with ocular hypertension (OHT), with a disc size 
      <1.63 mm2 or >2.43 mm2 underwent SD-OCT, confocal laser scanning tomography 
      (CSLT), visual field testing, and clinical examination. Bruch's membrane 
      opening-MRA BMO-MRW, RNFL thickness of SD-OCT and disc margin rim area (DM-RA) of 
      CSLT were evaluated and analyzed for diagnostic power to detect glaucoma. 
      RESULTS: In healthy eyes with macrodiscs, mean BMO-MRW of 243.14 +/- 43.12 mum was 
      significantly smaller than BMO-MRW in microdiscs (338.97 +/- 69.39; P < 0.001). 
      Bruch's membrane opening-MRA was comparable between disc size groups with 1.22 +/- 
      0.25 mm2 for macrodiscs and 1.26 +/- 0.27 mm2 for microdiscs (P = 0.51), as was 
      RNFL thickness (82.69 +/- 15.76 mum versus 78.53 +/- 11.01 mum, respectively; P = 
      0.28). Perimetric mean deviation was -8.7 +/- 6.3 dB in glaucoma and -0.6 +/- 1.60 dB 
      in OHT patients. Correlation of BMO-MRA and visual field function was rho (rho) = 
      0.70 (P < 0.001). Diagnostic power to differentiate glaucoma patients was highest 
      for BMO-MRA. Partial area under the curve (pAUC) for BMO-MRA was 0.14 for 
      specificity between 0.8 and 1.0, exceeding pAUCs of BMO-MRW (P < 0.001), RNFL 
      thickness (P = 0.03), and DM-RA (P = 0.01). CONCLUSIONS: Bruch's membrane 
      opening-based minimum rim area measurements offer advantages compared to 
      one-dimensional parameters assessing neuroretinal rim by SD-OCT. In 
      nonglaucomatous eyes, BMO-MRA values seem comparable for the full range of disc 
      sizes. Bruch's membrane opening-MRA surpasses other parameters in diagnostic 
      power for glaucoma.
FAU - Enders, Philip
AU  - Enders P
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
FAU - Adler, Werner
AU  - Adler W
AD  - Department of Medical Informatics, Biometry, and Epidemiology, 
      Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
FAU - Schaub, Friederike
AU  - Schaub F
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
FAU - Hermann, Manuel M
AU  - Hermann MM
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
FAU - Dietlein, Thomas
AU  - Dietlein T
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
FAU - Cursiefen, Claus
AU  - Cursiefen C
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
FAU - Heindl, Ludwig M
AU  - Heindl LM
AD  - Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bruch Membrane/*diagnostic imaging
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ocular Hypertension/diagnosis/physiopathology
MH  - Optic Disk/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Fields/*physiology
MH  - Young Adult
EDAT- 2016/12/13 06:00
MHDA- 2017/06/16 06:00
CRDT- 2016/12/13 06:00
PHST- 2016/12/13 06:00 [entrez]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
AID - 2592286 [pii]
AID - 10.1167/iovs.16-20561 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6596-6603. doi: 
      10.1167/iovs.16-20561.