PMID- 27951706
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20181004
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 32
IP  - 49
DP  - 2016 Dec 13
TI  - Competitive and Synergistic Interactions between Polymer Micelles, Drugs, and 
      Cyclodextrins: The Importance of Drug Solubilization Locus.
PG  - 13174-13186
AB  - Polymeric micelles, in particular PEO-PPO-based Pluronic, have emerged as 
      promising drug carriers, while cyclodextrins (CD), cyclic oligosaccharides with 
      an apolar cavity, have long been used for their capacity to form inclusion 
      complexes with drugs. Dimethylated beta-cyclodextrin (DIMEB) has the capacity to 
      fully breakup F127 Pluronic micelles, while this effect is substantially hindered 
      if drugs are loaded within the micellar aggregates. Four drugs were studied at 
      physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB), sodium 
      naproxen (NP), and sodium salicylate (SAL); higher temperatures shift the 
      equilibrium toward higher drug partitioning and lower drug/CD binding compared to 
      25  degrees C ( Valero, M.; Dreiss, C. A. Growth, Shrinking, and Breaking of Pluronic 
      Micelles in the Presence of Drugs and/or beta-Cyclodextrin, a Study by Small-Angle 
      Neutron Scattering and Fluorescence Spectroscopy . Langmuir 2010 , 26 , 10561 - 
      10571 ). The impact of drugs on micellar structure was characterized by 
      small-angle neutron scattering (SANS), while their solubilization locus was 
      revealed by 2D NOESY NMR. UV and fluorescence spectroscopy, Dynamic and Static 
      Light Scattering were employed to measure a range of micellar properties and 
      drug:CD interactions: binding constant, drug partitioning within the micelles, 
      critical micellar concentration of the loaded micelles, aggregation number 
      (N(agg)). Critically, time-resolved SANS (TR-SANS) reveal that micellar breakup 
      in the presence of drugs is substantially slower (100s of seconds) than for the 
      free micelles (<100 ms) ( Valero, M.; Grillo, I.; Dreiss, C. A. Rupture of 
      Pluronic Micelles by Di-Methylated beta-Cyclodextrin Is Not Due to 
      Polypseudorotaxane Formation . J. Phys. Chem. B 2012 , 116 , 1273 - 1281 ). These 
      results combined together give new insights into the mechanisms of protection of 
      the drugs against CD-induced micellar breakup. The outcomes are practical 
      guidelines to improve the design of drug delivery systems as well as a better 
      understanding of competitive assembly mechanisms leading to shape and function 
      modulation.
FAU - Valero, Margarita
AU  - Valero M
AD  - Dpto. Quimica Fisica, Facultad de Farmacia, Universidad de Salamanca , Campus 
      Miguel de Unamuno, s/n, 37007 Salamanca, Spain.
FAU - Castiglione, Franca
AU  - Castiglione F
AD  - Department of Chemistry, Materials and Chemical Engineering "G. Natta", 
      Politecnico di Milano , Piazza L. Da Vinci 32, I-20133 Milano, Italy.
FAU - Mele, Andrea
AU  - Mele A
AD  - Department of Chemistry, Materials and Chemical Engineering "G. Natta", 
      Politecnico di Milano , Piazza L. Da Vinci 32, I-20133 Milano, Italy.
FAU - da Silva, Marcelo A
AU  - da Silva MA
AD  - Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins 
      Building, 150 Stamford Street, London SE1 9NH, United Kingdom.
FAU - Grillo, Isabelle
AU  - Grillo I
AD  - Institut Laue Langevin , 71 avenue des martyrs, B.P. 156, 38042 Grenoble Cedex 9, 
      France.
FAU - Gonzalez-Gaitano, Gustavo
AU  - Gonzalez-Gaitano G
AD  - Departamento de Quimica, Universidad de Navarra , 31080 Pamplona, Spain.
FAU - Dreiss, Cecile A
AU  - Dreiss CA
AD  - Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins 
      Building, 150 Stamford Street, London SE1 9NH, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20161201
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Cyclodextrins)
RN  - 0 (Micelles)
RN  - 0 (Pharmaceutical Preparations)
RN  - 106392-12-5 (Poloxamer)
RN  - 57Y76R9ATQ (Naproxen)
RN  - 98PI200987 (Lidocaine)
RN  - I4744080IR (Pentobarbital)
RN  - WIQ1H85SYP (Sodium Salicylate)
SB  - IM
MH  - Cyclodextrins/*chemistry
MH  - Lidocaine
MH  - *Micelles
MH  - Naproxen
MH  - Pentobarbital
MH  - Pharmaceutical Preparations/*chemistry
MH  - Poloxamer/*chemistry
MH  - Scattering, Small Angle
MH  - Sodium Salicylate
EDAT- 2016/12/14 06:00
MHDA- 2018/09/19 06:00
CRDT- 2016/12/14 06:00
PHST- 2016/12/14 06:00 [entrez]
PHST- 2016/12/14 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
AID - 10.1021/acs.langmuir.6b03367 [doi]
PST - ppublish
SO  - Langmuir. 2016 Dec 13;32(49):13174-13186. doi: 10.1021/acs.langmuir.6b03367. Epub 
      2016 Dec 1.