PMID- 27955661
OWN - NLM
STAT- MEDLINE
DCOM- 20170605
LR  - 20220310
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 16
IP  - 1
DP  - 2016 Dec 13
TI  - Association between neutrophilic granulocyte percentage and depression in 
      hospitalized patients with heart failure.
PG  - 446
LID - 446
AB  - BACKGROUND: Previous researches reveal that depression is associated with 
      increased inflammatory markers. As a simple and cheap inflammatory marker, we 
      hypothesize that neutrophilic granulocyte percentage is associated with 
      depression in hospitalized heart failure patients, whose prevalence of depression 
      is at a very high level. METHODS: Three hundred sixty-six cases of hospitalized 
      heart failure patients with left ventricular ejection fraction (LVEF) </=45% and 
      New York Heart Association (NYHA) class II-IV were enrolled. All the enrolled 
      patients received Hamilton Rating Scale for Depression (24-items) (HAM-D(24)). 
      The demographic, clinical data, blood samples and echocardiography were 
      documented. The Pearson simple linear correlation was performed to evaluate the 
      confounding factors correlated with HAM-D(24) depression index. The significantly 
      correlated factors were enrolled as independent variables in Logistic regression 
      to determine the risk or protective factors for depression, which was taken as 
      dependent variable. RESULTS: Two hundred ten cases of hospitalized heart failure 
      patients (57.4%) had depression. Among them, 134 patients (63.8%) had mild 
      depression, 58 patients (27.6%) had moderate depression and 18 patients (8.6%) 
      had severe depression. Pearson simple linear correlation revealed that in 
      hospitalized patients with heart failure, the neutrophils granulocyte percentage 
      was positively correlated with the HAM-D(24) depression index (r = .435, 
      p < .001). After the adjustment of age, BMI, number of members of the household, 
      smoking index, New York Heart Association (NYHA) classification, hemoglobin, TC, 
      LDL-C, creatinine, cystatin-C, TBIL and albumin, the neutrophils granulocyte 
      percentage is still significantly associated with depression in hospitalized 
      heart failure patients (OR = 1.046, p < .001). CONCLUSIONS: The neutrophils 
      granulocyte percentage may be used as a new marker for depression in hospitalized 
      heart failure patients.
FAU - Pan, Shuo
AU  - Pan S
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Liu, Zhong-Wei
AU  - Liu ZW
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Lv, Ying
AU  - Lv Y
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Song, Wen-Qian
AU  - Song WQ
AD  - Department of Internal Medicine, University Hospital of Northwest University, 
      Xi'an, Shaanxi, People's Republic of China.
FAU - Ma, Xun
AU  - Ma X
AD  - Department of Emergency Medicine, People's Hospital of Shaanxi Province, Xi'an, 
      Shaanxi, People's Republic of China.
FAU - Guan, Gong-Chang
AU  - Guan GC
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Zhu, Shun-Ming
AU  - Zhu SM
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Liu, Fu-Qiang
AU  - Liu FQ
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Liu, Bo
AU  - Liu B
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Tang, Zhi-Guo
AU  - Tang ZG
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China.
FAU - Wang, Jun-Kui
AU  - Wang JK
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      710068, Shaanxi, People's Republic of China. wjk_sx@163.com.
LA  - eng
PT  - Journal Article
DEP - 20161213
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
SB  - IM
MH  - Aged
MH  - Depression/*blood/etiology
MH  - Female
MH  - Granulocytes/*metabolism
MH  - Heart Failure/*blood/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Natriuretic Peptide, C-Type/blood
MH  - Prevalence
MH  - Ventricular Function, Left
PMC - PMC5154115
OTO - NOTNLM
OT  - Depression
OT  - Hospitalized heart failure
OT  - Neutrophilic granulocyte percentage
EDAT- 2016/12/14 06:00
MHDA- 2017/06/06 06:00
PMCR- 2016/12/13
CRDT- 2016/12/14 06:00
PHST- 2016/08/02 00:00 [received]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2016/12/14 06:00 [entrez]
PHST- 2016/12/14 06:00 [pubmed]
PHST- 2017/06/06 06:00 [medline]
PHST- 2016/12/13 00:00 [pmc-release]
AID - 10.1186/s12888-016-1161-6 [pii]
AID - 1161 [pii]
AID - 10.1186/s12888-016-1161-6 [doi]
PST - epublish
SO  - BMC Psychiatry. 2016 Dec 13;16(1):446. doi: 10.1186/s12888-016-1161-6.