PMID- 27956250
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20180421
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 67
DP  - 2017 Jan
TI  - Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal 
      growth restriction in a stage-specific but gender-independent manner.
PG  - 117-124
LID - S0890-6238(16)30470-1 [pii]
LID - 10.1016/j.reprotox.2016.12.003 [doi]
AB  - Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs 
      testis development with reduced anogenital distance. The present study aimed to 
      investigate whether maternal DEHP exposure during pregnancy causes intrauterine 
      growth restriction (IUGR) in a gender-specific manner and to identify the 
      critical window of DEHP-induced fetal IUGR. Pregnant mice were administered with 
      DEHP (0, 50 or 200mg/kg) by gavage. Fetal IUGR was observed not only in males but 
      also in females when litters were exposed to DEHP on gestational day (GD)0-GD17. 
      Interestingly, fetal weight and crown-rump length were reduced, markedly in dams 
      with DEHP on GD13-GD17, slightly in dams with on GD7-GD12, but not in dams with 
      on GD0-GD6. Further analysis showed that maternal DEHP exposure on GD7-GD12 
      inhibited cell proliferation, lowered placental weight, and reduced blood 
      sinusoid area in placental labyrinth layer. These results suggest that maternal 
      DEHP exposure induces IUGR in a stage-specific but gender-independent manner.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Shen, Ru
AU  - Shen R
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China.
FAU - Zhao, Ling-Li
AU  - Zhao LL
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China.
FAU - Yu, Zhen
AU  - Yu Z
AD  - Department of Maternal, Child & Adolescent Health, Anhui Medical University, 
      China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China; Department of 
      Histology and Embryology, Anhui Medical University, Hefei, 230032, China. 
      Electronic address: yuanhuach@126.com.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China.
FAU - Zhang, Zhi-Hui
AU  - Zhang ZH
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, Anhui Medical University, China; Laboratory of 
      Environmental Toxicology, Anhui Medical University, China. Electronic address: 
      xudex@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161209
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Environmental Pollutants)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Crown-Rump Length
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Fetal Growth Retardation/*chemically induced
MH  - Gestational Age
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Mice, Inbred ICR
MH  - Organ Size/drug effects
MH  - Placenta/drug effects
MH  - Pregnancy
MH  - Sex Factors
OTO - NOTNLM
OT  - Developmental toxicity
OT  - Di (2-ethylhexyl) phthalate (DEHP)
OT  - Endocrine disrupting chemicals
OT  - Intrauterine growth restriction (IUGR)
EDAT- 2016/12/14 06:00
MHDA- 2018/01/23 06:00
CRDT- 2016/12/14 06:00
PHST- 2016/08/10 00:00 [received]
PHST- 2016/11/13 00:00 [revised]
PHST- 2016/12/06 00:00 [accepted]
PHST- 2016/12/14 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
PHST- 2016/12/14 06:00 [entrez]
AID - S0890-6238(16)30470-1 [pii]
AID - 10.1016/j.reprotox.2016.12.003 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Jan;67:117-124. doi: 10.1016/j.reprotox.2016.12.003. Epub 
      2016 Dec 9.