PMID- 27958346
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Dec 13
TI  - Clinical Association of Chemokine (C-X-C motif) Ligand 1 (CXCL1) with 
      Interstitial Pneumonia with Autoimmune Features (IPAF).
PG  - 38949
LID - 10.1038/srep38949 [doi]
LID - 38949
AB  - The term "interstitial pneumonia with autoimmune features" (IPAF) has been 
      recently proposed. We here investigate the clinical characteristics of IPAF and 
      evaluate the clinical implications of CXCL1-CXCR2 axis in IPAF. An increased 
      plasma level of CXCL1 was exhibited in IPAF compared to idiopathic interstitial 
      pneumonia (IIP), chronic obstructive pulmonary disease (COPD), and healthy 
      controls. Additionally, plasma CXCL1 levels were clinically associated with 
      diffusing capacity of the lungs for carbon monoxide (DLCO), erythrocyte 
      sedimentation rate (ESR), and involved parenchyma extension in IPAF. Furthermore, 
      circulating CXCL1 levels were highest in IPAF patients with acute exacerbations. 
      CXCR2, the chemokine receptor for CXCL1, was readily observed in inflammatory 
      aggregates and endothelial cells in IPAF lungs, but was lower in IIP lungs and 
      healthy lungs. Interestingly, increased CXCL1 concentrations in BALF paralleled 
      neutrophil counts in IPAF. Overall, the plasma concentrations of CXCL1 indicated 
      the disease activity and prognosis in IPAF. Thus, the CXCL1/CXCR2 axis appears to 
      be involved in the progression of IPAF.
FAU - Liang, Minrui
AU  - Liang M
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Jiang, Zhixing
AU  - Jiang Z
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Huang, Qiong
AU  - Huang Q
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
FAU - Liu, Lei
AU  - Liu L
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Xue, Yu
AU  - Xue Y
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Zhu, Xiaoxia
AU  - Zhu X
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Yu, Yiyun
AU  - Yu Y
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Wan, Weiguo
AU  - Wan W
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Yang, Haihua
AU  - Yang H
AD  - Department of Pulmonology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
FAU - Zou, Hejian
AU  - Zou H
AD  - Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
AD  - Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 
      200040, P.R. China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161213
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (CXCL1 protein, human)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Receptors, Interleukin-8B)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Aged
MH  - Autoimmune Diseases/*blood
MH  - Blood Sedimentation
MH  - Carbon Monoxide/blood
MH  - Chemokine CXCL1/*blood
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*blood
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/blood
MH  - Receptors, Interleukin-8B/blood
PMC - PMC5154180
EDAT- 2016/12/14 06:00
MHDA- 2018/06/13 06:00
PMCR- 2016/12/13
CRDT- 2016/12/14 06:00
PHST- 2016/06/16 00:00 [received]
PHST- 2016/11/16 00:00 [accepted]
PHST- 2016/12/14 06:00 [entrez]
PHST- 2016/12/14 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2016/12/13 00:00 [pmc-release]
AID - srep38949 [pii]
AID - 10.1038/srep38949 [doi]
PST - epublish
SO  - Sci Rep. 2016 Dec 13;6:38949. doi: 10.1038/srep38949.