PMID- 27960188
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20181202
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 43
IP  - 1-3
DP  - 2017
TI  - Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis 
      Patients: A Systematic Review and Meta-Analysis.
PG  - 101-122
LID - 10.1159/000453444 [doi]
AB  - INTRODUCTION: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) 
      might improve the clinical management of chronic hemodialysis (HD) patients. 
      METHODS: We conducted a systematic review and meta-analysis of RCTs comparing 
      ViE-m to conventional HD. Endpoints of interest were a series of biomarkers 
      pertaining to anemia status, inflammation, oxidative stress and dialysis 
      efficacy/status. RESULTS: Sixty studies were included. ViE-m significantly 
      improved the Erythropoietin Resistance Index but had no impact on other anemia 
      parameters. As for oxidative stress and inflammation, ViE-m produced a 
      significant decrease in interleukin-6 levels, thiobarbituric acid reactive 
      substances, plasma and red blood cell (RBC) malonylaldehyde and a significant 
      increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid 
      profile, dialysis adequacy, blood pressure, albumin and uric acid. CONCLUSIONS: 
      ViE-m might ameliorate anemia management by reducing oxidative stress and 
      inflammation. Benefits of these bio-membranes on harder clinical outcomes are 
      uncertain and need to be investigated by future, targeted trials.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - D'Arrigo, Graziella
AU  - D'Arrigo G
AD  - CNR - Institute of Clinical Physiology, Reggio Calabria, Italy.
FAU - Baggetta, Rossella
AU  - Baggetta R
FAU - Tripepi, Giovanni
AU  - Tripepi G
FAU - Galli, Francesco
AU  - Galli F
FAU - Bolignano, Davide
AU  - Bolignano D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161214
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Membranes, Artificial)
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Anemia/prevention & control
MH  - Coated Materials, Biocompatible/*standards
MH  - Humans
MH  - Inflammation/prevention & control
MH  - Kidney Failure, Chronic/therapy
MH  - *Membranes, Artificial
MH  - Oxidative Stress/drug effects
MH  - Renal Dialysis/adverse effects/*instrumentation
MH  - Vitamin E/*pharmacology
EDAT- 2016/12/14 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/12/14 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2016/11/15 00:00 [accepted]
PHST- 2016/12/14 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
PHST- 2016/12/14 06:00 [entrez]
AID - 000453444 [pii]
AID - 10.1159/000453444 [doi]
PST - ppublish
SO  - Blood Purif. 2017;43(1-3):101-122. doi: 10.1159/000453444. Epub 2016 Dec 14.