PMID- 27965249
OWN - NLM
STAT- MEDLINE
DCOM- 20171129
LR  - 20190202
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 6
IP  - 12
DP  - 2016 Dec 13
TI  - Prevalence of type 2 diabetes mellitus in women of childbearing age in Africa 
      during 2000-2016: protocol of a systematic review and meta-analysis.
PG  - e012255
LID - 10.1136/bmjopen-2016-012255 [doi]
LID - e012255
AB  - INTRODUCTION: African women of childbearing age are increasingly being exposed to 
      risk factors for type 2 diabetes mellitus (T2DM), most particularly obesity. A 
      differentiating feature of diabetes in women of childbearing age is that the 
      disease may affect the mother and the developing fetus. Apart from mapping the 
      extent of the problem, understanding the prevalence of T2DM in African women of 
      childbearing age can help to galvanise targeted interventions for reducing the 
      burden of T2DM. This is a protocol for a systematic review aiming to assess the 
      prevalence of and risk factors for T2DM in women of childbearing age 
      (15-49 years) in Africa. METHODS AND ANALYSES: We will carry out a comprehensive 
      literature search among a number of databases, using appropriate adaptations of 
      the African search filter to identify diabetes prevalence studies, published from 
      2000 to 2016, among African women of childbearing age (15-49 years) according to 
      the WHO definition. Full copies of articles identified through searches and 
      considered to meet the inclusion criteria will be obtained for data extraction 
      and synthesis. The analysis of the primary outcome (prevalent diabetes) will 
      include two steps: (1) identification of data sources and documenting estimates 
      and (2) application of the random-effects meta-analysis model to aggregate 
      prevalence estimates and account for between-study variability in calculating the 
      overall pooled estimates and 95% CI for diabetes prevalence. We will assess 
      heterogeneity and publication bias using established methods. This systematic 
      review will be reported according to the Preferred Reporting Items for Systematic 
      reviews and Meta-Analyses Protocol (PRISMA-P) 2015. ETHICS AND DISSEMINATION: 
      Ethical approval is not required for this study, given that this is a protocol 
      for a systematic review, which utilises published data. The findings of this 
      study will be widely disseminated through peer reviewed publications and 
      conference presentations. TRIAL REGISTRATION NUMBER: CRD42015027635.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Chivese, Tawanda
AU  - Chivese T
AUID- ORCID: 0000-0001-6621-6144
AD  - Chronic Disease Initiative for Africa, Department of Medicine, University of Cape 
      Town, South Africa.
AD  - Faculty of Health Sciences, South Africa Medical Research Council Developmental 
      Pathways for Health Research Unit, Department of Paediatrics, University of the 
      Witwatersrand, Johannesburg, South Africa.
FAU - Mahmoud, Werfalli
AU  - Mahmoud W
AD  - Chronic Disease Initiative for Africa, Department of Medicine, University of Cape 
      Town, South Africa.
FAU - Magodoro, Itai
AU  - Magodoro I
AD  - Harvard Medical School, Boston, USA.
FAU - Kengne, Andre P
AU  - Kengne AP
AD  - Non-communicable Disease Research Unit, South African Medical Research Council, 
      Cape Town, South Africa.
FAU - Norris, Shane A
AU  - Norris SA
AD  - Faculty of Health Sciences, South Africa Medical Research Council Developmental 
      Pathways for Health Research Unit, Department of Paediatrics, University of the 
      Witwatersrand, Johannesburg, South Africa.
FAU - Levitt, Naomi S
AU  - Levitt NS
AD  - Division of Endocrinology, Department of Medicine, University of Cape Town, Cape 
      Town, South Africa.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20161213
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/complications
MH  - Pregnancy
MH  - Prevalence
MH  - Publication Bias
MH  - Research Design
MH  - Risk Factors
MH  - Systematic Reviews as Topic
MH  - Young Adult
PMC - PMC5168695
OTO - NOTNLM
OT  - DIABETES & ENDOCRINOLOGY
OT  - EPIDEMIOLOGY
COIS- Conflicts of Interest: None declared.
EDAT- 2016/12/15 06:00
MHDA- 2017/12/01 06:00
PMCR- 2016/12/12
CRDT- 2016/12/15 06:00
PHST- 2016/12/15 06:00 [entrez]
PHST- 2016/12/15 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
PHST- 2016/12/12 00:00 [pmc-release]
AID - bmjopen-2016-012255 [pii]
AID - 10.1136/bmjopen-2016-012255 [doi]
PST - epublish
SO  - BMJ Open. 2016 Dec 13;6(12):e012255. doi: 10.1136/bmjopen-2016-012255.