PMID- 27965904 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200929 IS - 2090-6625 (Print) IS - 2090-6633 (Electronic) VI - 2016 DP - 2016 TI - Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy. PG - 8915047 LID - 8915047 AB - Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. Immune reconstitution inflammatory syndrome (IRIS), on the other hand, is a condition of inflammation that develops as the immune system reconstitutes. This case report describes a case of a 35-year-old HIV-negative male who presented with three weeks of right lower extremity paresthesias as well as right upper extremity apraxia. He was diagnosed with PML complicated by IRIS secondary to Rituximab, which he had completed four months prior to presentation. Despite the condition's poor prognosis, the patient recovered with only minor deficits. FAU - Punch, Chandra AU - Punch C AUID- ORCID: 0000-0002-2093-7066 AD - Madigan Army Medical Center, Tacoma, WA, USA. FAU - Schofield, Christina AU - Schofield C AD - Madigan Army Medical Center, Tacoma, WA, USA. FAU - Harris, Penelope AU - Harris P AD - Madigan Army Medical Center, Tacoma, WA, USA. LA - eng PT - Journal Article DEP - 20161114 PL - Egypt TA - Case Rep Infect Dis JT - Case reports in infectious diseases JID - 101573243 PMC - PMC5124683 COIS- The authors declare that there are no competing interests regarding the publication of this paper. EDAT- 2016/12/15 06:00 MHDA- 2016/12/15 06:01 PMCR- 2016/11/14 CRDT- 2016/12/15 06:00 PHST- 2016/07/05 00:00 [received] PHST- 2016/09/14 00:00 [revised] PHST- 2016/10/20 00:00 [accepted] PHST- 2016/12/15 06:00 [entrez] PHST- 2016/12/15 06:00 [pubmed] PHST- 2016/12/15 06:01 [medline] PHST- 2016/11/14 00:00 [pmc-release] AID - 10.1155/2016/8915047 [doi] PST - ppublish SO - Case Rep Infect Dis. 2016;2016:8915047. doi: 10.1155/2016/8915047. Epub 2016 Nov 14.