PMID- 27965983
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without 
      Diabetic Peripheral Neuropathy.
PG  - 4370490
LID - 4370490
AB  - This study investigated the relationship between serum xanthine oxidase (XOD) 
      activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 
      diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin 
      (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation 
      end products (AGE), total free thiols, atherogenic index of plasma (AIP), and 
      body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without 
      DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, 
      medication, and microalbuminuria was recorded. Serum XOD activities in controls, 
      non-DPN, and DPN were 5.7 +/- 2.4 U/L, 20.3 +/- 8.6 U/L, and 27.5 +/- 10.6 U/L (p < 
      0.01), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, 
      and AGE, while inversely correlated to serum total free thiols. A multivariable 
      logistic regression model, which included duration of diabetes, hypertension, 
      AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00-1.05); p = 
      0.034] and XOD activity [OR = 1.07 (1.00-1.14); p = 0.036] as independent 
      predictors of DPN. Serum XOD activity was well correlated to several other risk 
      factors. These results indicate the role of XOD in the development of DPN among 
      T2DM patients.
FAU - Miric, Dijana J
AU  - Miric DJ
AUID- ORCID: 0000-0002-7126-1625
AD  - Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska 
      Mitrovica, Serbia.
FAU - Kisic, Bojana M
AU  - Kisic BM
AUID- ORCID: 0000-0002-3018-1186
AD  - Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska 
      Mitrovica, Serbia.
FAU - Filipovic-Danic, Snezana
AU  - Filipovic-Danic S
AD  - Clinics for Neurology and Psychiatry, Medical Faculty, University of Pristina, 
      Kosovska Mitrovica, Serbia.
FAU - Grbic, Rade
AU  - Grbic R
AUID- ORCID: 0000-0002-3344-5837
AD  - Clinics for General and Orthopedics Surgery, Medical Faculty, University of 
      Pristina, Kosovska Mitrovica, Serbia.
FAU - Dragojevic, Ilija
AU  - Dragojevic I
AUID- ORCID: 0000-0002-2292-7486
AD  - Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska 
      Mitrovica, Serbia.
FAU - Miric, Marko B
AU  - Miric MB
AD  - Clinics for Neurology and Psychiatry, Medical Faculty, University of Pristina, 
      Kosovska Mitrovica, Serbia.
FAU - Puhalo-Sladoje, Dragana
AU  - Puhalo-Sladoje D
AD  - Biochemical Laboratory, Medical Faculty, University of East Sarajevo, Foca, 
      Bosnia And Herzegovina.
LA  - eng
PT  - Journal Article
DEP - 20161114
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (ischemia-modified albumin)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
RN  - ZIF514RVZR (Serum Albumin, Human)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Diabetic Neuropathies/etiology/*metabolism
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Glycation End Products, Advanced/metabolism
MH  - Humans
MH  - Hypertension/complications
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Serum Albumin/metabolism
MH  - Serum Albumin, Human
MH  - Sulfhydryl Compounds/metabolism
MH  - Time Factors
MH  - Uric Acid/metabolism
MH  - Xanthine Oxidase/*metabolism
PMC - PMC5124663
COIS- The authors declare no competing financial or other interests regarding this 
      manuscript.
EDAT- 2016/12/15 06:00
MHDA- 2017/06/28 06:00
PMCR- 2016/11/14
CRDT- 2016/12/15 06:00
PHST- 2016/09/08 00:00 [received]
PHST- 2016/10/22 00:00 [revised]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/12/15 06:00 [entrez]
PHST- 2016/12/15 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
PHST- 2016/11/14 00:00 [pmc-release]
AID - 10.1155/2016/4370490 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:4370490. doi: 10.1155/2016/4370490. Epub 2016 Nov 14.