PMID- 2796602
OWN - NLM
STAT- MEDLINE
DCOM- 19891109
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 45
IP  - 13
DP  - 1989
TI  - Acetylcholine in the posterior hypothalamic nucleus is involved in the elevated 
      blood pressure in the spontaneously hypertensive rat.
PG  - 1163-70
AB  - Intravenous injection of physostigmine, 40 and 80 ug/kg, in unanesthetized 
      normotensive rats increased systolic blood pressure (SBP) by 21 +/- 3 and 42 +/- 
      7 mmHg. This pressor response was 80% inhibited by intracerebroventricular (icv) 
      injection of hemicholinium-3 (HC-3), 20 ug. Simultaneous icv injection of HC-3 
      and choline (365 ug) prevented the inhibition of the pressor response by HC-3. In 
      spontaneously hypertensive rats, injection of HC-3 either icv (20 ug) or 
      bilaterally into the posterior hypothalamic nuclei (1 ug) decreased SBP by about 
      40 mmHg. The effect of intrahypothalamic HC-3 was completely blocked by 
      simultaneous injection of choline (24.3 ug) into the same site. The hypotensive 
      effect of icv HC-3 was completely blocked by icv choline (243 ug) and was 
      inhibited up to 60% by injections of choline (24.3 ug) into the posterior 
      hypothalamic nuclei.
FAU - Brezenoff, H E
AU  - Brezenoff HE
AD  - Department of Pharmacology, University of Medicine and Dentistry of New Jersey, 
      Newark 07103.
FAU - Xiao, Y F
AU  - Xiao YF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 312-45-8 (Hemicholinium 3)
RN  - 9U1VM840SP (Physostigmine)
RN  - N91BDP6H0X (Choline)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*physiology
MH  - Animals
MH  - Blood Pressure/drug effects/*physiology
MH  - Choline/administration & dosage/pharmacology
MH  - Hemicholinium 3/administration & dosage/pharmacology
MH  - Hypertension/*physiopathology
MH  - Hypothalamus/drug effects/*physiology
MH  - Injections, Intraventricular
MH  - Kinetics
MH  - Male
MH  - Physostigmine/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 0024-3205(89)90504-3 [pii]
AID - 10.1016/0024-3205(89)90504-3 [doi]
PST - ppublish
SO  - Life Sci. 1989;45(13):1163-70. doi: 10.1016/0024-3205(89)90504-3.