PMID- 27975336
OWN - NLM
STAT- MEDLINE
DCOM- 20170830
LR  - 20170921
IS  - 1438-8812 (Electronic)
IS  - 0013-726X (Linking)
VI  - 49
IP  - 1
DP  - 2017 Jan
TI  - Growth rate of small pancreatic neuroendocrine tumors in multiple endocrine 
      neoplasia type 1: results from an endoscopic ultrasound based cohort study.
PG  - 27-34
LID - 10.1055/s-0042-119402 [doi]
AB  - Background and aims In multiple endocrine neoplasia type 1 (MEN1), endoscopic 
      ultrasound (EUS) is used for identification and follow-up of pancreatic 
      neuroendocrine tumors (PNETs). The role of EUS in surveillance of small 
      ( < 20 mm) PNETs is unclear, mostly because the natural course of these lesions 
      is largely unknown. We aimed to determine annual growth and incidence rate of 
      small PNETs in patients with MEN1 using EUS-based surveillance. Patients and 
      methods Linear array EUS procedures in patients with MEN1 between 2002 and 2015 
      were identified. Number, size, and location of PNETs were recorded. Annual growth 
      of PNETs < 20 mm identified at the initial EUS ("prevalent" PNETs) and during 
      follow-up ("incident" PNETs) was calculated using mixed model linear regression 
      analysis. Results A total of 54 patients were identified and 38 patients were 
      included. In all, 226 PNETs were identified (median size 5.0 mm, interquartile 
      range 3.7 - 7.5) of which 124 (55 %) were prevalent and 102 (45 %) were incident 
      PNETs. Annual incidence rate was 0.79 PNETs/year (95 % confidence interval [CI] 
      0.73 to 0.87). Overall growth rate was 0.10 mm/year (95 %CI 0.02 to 0.19; 
      P = 0.01); PNETs < 10 mm (n = 198) did not grow (P = 0.23), whereas PNETs >/= 10 mm 
      (n = 28) grew 0.44 mm/year (95 %CI 0.10 to 0.78; P = 0.01). Prevalent PNETs grew 
      0.21 mm/year (95 %CI 0.10 - 0.32; P < 0.001), whereas incident PNETs did not grow 
      (P = 0.26). Conclusions The annual growth rate of small, solid PNETs in patients 
      with MEN1 is lower than previously thought. Surveillance intervals could probably 
      be prolonged without compromising safety.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Kappelle, Wouter F W
AU  - Kappelle WF
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Valk, Gerlof D
AU  - Valk GD
AD  - Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Leenders, Max
AU  - Leenders M
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Moons, Leon M G
AU  - Moons LM
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Bogte, Auke
AU  - Bogte A
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Siersema, Peter D
AU  - Siersema PD
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Vleggaar, Frank P
AU  - Vleggaar FP
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20161214
PL  - Germany
TA  - Endoscopy
JT  - Endoscopy
JID - 0215166
SB  - IM
CIN - Endoscopy. 2017 Jan;49(1):103. PMID: 28068723
MH  - Adult
MH  - *Endosonography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Neuroendocrine Tumors/*diagnostic imaging/pathology/surgery
MH  - Pancreatic Neoplasms/*diagnostic imaging/pathology/surgery
MH  - *Population Surveillance
MH  - Prospective Studies
MH  - *Tumor Burden
EDAT- 2016/12/16 06:00
MHDA- 2017/08/31 06:00
CRDT- 2016/12/16 06:00
PHST- 2016/12/16 06:00 [pubmed]
PHST- 2017/08/31 06:00 [medline]
PHST- 2016/12/16 06:00 [entrez]
AID - 10.1055/s-0042-119402 [doi]
PST - ppublish
SO  - Endoscopy. 2017 Jan;49(1):27-34. doi: 10.1055/s-0042-119402. Epub 2016 Dec 14.