PMID- 27976800
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20210109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 31
IP  - 5
DP  - 2017 Sep
TI  - Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid 
      adenosine deaminase and pleural fluid carcinoembryonic antigen in the 
      identification of malignant pleural effusion.
LID - 10.1002/jcla.22106 [doi]
LID - e22106
AB  - BACKGROUND: Limited data are available for the diagnostic value, and for the 
      diagnostic sensitivity and specificity of joint detection of serum lactate 
      dehydrogenase (sLDH)/pleural fluid adenosine deaminase (pADA) and pleural fluid 
      carcinoembryonic antigen (pCEA) in malignant pleural effusion (MPE). METHODS: We 
      collected 987 pleural effusion specimens (of which 318 were malignant pleural 
      effusion, 374 were tubercular pleural effusion, and 295 were parapneumonic 
      effusion specimens) from the First Affiliated Hospital of Wenzhou Medical 
      University from July 2012 to March 2016. The pADA, sLDH, pleural fluid LDH 
      (pLDH), serum C-reactive protein (sCRP), pleural fluid protein, pCEA, white blood 
      cell (WBC), and red blood cell (RBC) were analyzed, and the clinical data of each 
      group were collected for statistical analysis. RESULTS: The level of sLDH/pADA, 
      pCEA, and RBC from the MPE group was markedly higher than the tuberculosis 
      pleural effusion (TB) group (Mann-Whitney U=28422.000, 9278.000, 30518, P=.000, 
      .000, .000) and the parapneumonic pleural fluid group (Mann-Whitney U=5972.500, 
      7113.000, 36750.500, P=.000, .000, .000). The receiver operating characteristic 
      curve ROC showed that the area under the ROC curve (AUC) (=0.924, 0.841) of pCEA 
      and sLDH/pADA (cutoff=4.9, 10.6) were significantly higher than other markers for 
      the diagnosis of MPE. Thus, joint detection of pCEA and sLDH/pADA suggested that 
      the sensitivity, specificity, and AUC was 0.94, 81.70, and 94.32 at the cutoff 
      0.16 and diagnostic performance was higher than pCEA or sLDH/pADA. CONCLUSION: 
      Joint detection of sLDH/pADA and pCEA can be used as a good indicator for the 
      identification of benign and MPE with higher sensitivity and specificity than 
      pCEA or sLDH/pADA.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Zhang, Fan
AU  - Zhang F
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Hu, Lijuan
AU  - Hu L
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Wang, Junjun
AU  - Wang J
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Chen, Jian
AU  - Chen J
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Wang, Yumin
AU  - Wang Y
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20161215
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Carcinoembryonic Antigen)
RN  - EC 1.1.- (Lactate Dehydrogenases)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Adenosine Deaminase/*blood
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoembryonic Antigen/*analysis
MH  - Female
MH  - Humans
MH  - Lactate Dehydrogenases/*blood
MH  - Male
MH  - Middle Aged
MH  - *Pleural Effusion, Malignant/blood/diagnosis/enzymology/epidemiology
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC6817298
OTO - NOTNLM
OT  - malignant pleural effusion
OT  - pleural fluid carcinoembryonic antigen
OT  - serum lactate dehydrogenase/pleural fluid adenosine deaminase
EDAT- 2016/12/16 06:00
MHDA- 2018/05/08 06:00
PMCR- 2016/12/15
CRDT- 2016/12/16 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2016/11/09 00:00 [accepted]
PHST- 2016/12/16 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2016/12/16 06:00 [entrez]
PHST- 2016/12/15 00:00 [pmc-release]
AID - JCLA22106 [pii]
AID - 10.1002/jcla.22106 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2017 Sep;31(5):e22106. doi: 10.1002/jcla.22106. Epub 2016 Dec 
      15.