PMID- 27977881
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20170614
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 81
IP  - 1
DP  - 2017 Jan
TI  - Immune activation in amniotic fluid from Zika virus-associated microcephaly.
PG  - 152-156
LID - 10.1002/ana.24839 [doi]
AB  - Recent advances in the understanding of neuropathogenesis associated with Zika 
      virus (ZIKV) infection has led to descriptions of neonatal microcephaly cases. 
      However, none of these reports have evaluated the humoral response during ZIKV 
      infection. We report here polyfunctional immune activation associated with 
      increased interferon-gamma-inducible protein 10, interleukin (IL)-6, IL-8, 
      vascular endothelial growth factor (VEGF), monocyte chemoattractive protein 1 
      (MCP-1), and granulocyte colony-stimulating factor (G-CSF) levels in the amniotic 
      fluid of ZIKV-positive pregnant women with neonatal microcephaly. These cytokines 
      have been associated not only with neuronal damage, but also with differentiation 
      and proliferation of neural progenitor cells. Our results suggested that the 
      immune activation caused by ZIKV infection in the uterine environment could also 
      interfere with fetal development. ANN NEUROL 2017;81:152-156.
CI  - (c) 2016 American Neurological Association.
FAU - Ornelas, Alice M M
AU  - Ornelas AM
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
FAU - Pezzuto, Paula
AU  - Pezzuto P
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
FAU - Silveira, Paola P
AU  - Silveira PP
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
FAU - Melo, Fabiana O
AU  - Melo FO
AD  - Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, 
      Paraiba, Brazil.
FAU - Ferreira, Thales A
AU  - Ferreira TA
AD  - Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, 
      Paraiba, Brazil.
FAU - Oliveira-Szejnfeld, Patricia S
AU  - Oliveira-Szejnfeld PS
AD  - Fundacao Instituto de Ensino e Pesquisa em Diagnostico por Imagem (FIDI), 
      Departamento de Diagnostico por Imagem, Universidade Federal de Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Leal, Jeime I
AU  - Leal JI
AD  - Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, 
      Paraiba, Brazil.
FAU - Amorim, Melania M R
AU  - Amorim MM
AD  - Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, 
      Paraiba, Brazil.
FAU - Hamilton, Stuart
AU  - Hamilton S
AD  - Virology Research, POWH & UNSW Research Laboratories, Prince of Wales Hospital, 
      Randwick, NSW, Australia.
FAU - Rawlinson, William D
AU  - Rawlinson WD
AD  - Virology Research, POWH & UNSW Research Laboratories, Prince of Wales Hospital, 
      Randwick, NSW, Australia.
FAU - Cardoso, Cynthia C
AU  - Cardoso CC
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
FAU - Nixon, Douglas F
AU  - Nixon DF
AD  - Department of Microbiology, Immunology & Tropical Medicine, The George Washington 
      University, Washington, DC.
FAU - Tanuri, Amilcar
AU  - Tanuri A
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
FAU - Melo, Adriana S
AU  - Melo AS
AD  - Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, 
      Paraiba, Brazil.
FAU - Aguiar, Renato S
AU  - Aguiar RS
AD  - Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amniotic Fluid/*immunology/metabolism
MH  - Case-Control Studies
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CXCL10/metabolism
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/metabolism
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/metabolism
MH  - Microcephaly/*etiology/*immunology/metabolism/pathology
MH  - Neural Stem Cells/cytology/immunology/metabolism
MH  - Pregnancy
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Young Adult
MH  - Zika Virus Infection/*complications/*immunology/metabolism/pathology
EDAT- 2016/12/16 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/12/16 06:00
PHST- 2016/07/06 00:00 [received]
PHST- 2016/12/02 00:00 [revised]
PHST- 2016/12/03 00:00 [accepted]
PHST- 2016/12/16 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
PHST- 2016/12/16 06:00 [entrez]
AID - 10.1002/ana.24839 [doi]
PST - ppublish
SO  - Ann Neurol. 2017 Jan;81(1):152-156. doi: 10.1002/ana.24839.