PMID- 27979044 OWN - NLM STAT- MEDLINE DCOM- 20170525 LR - 20220129 IS - 1097-6744 (Electronic) IS - 0002-8703 (Print) IS - 0002-8703 (Linking) VI - 183 DP - 2017 Jan TI - Serum brain-derived neurotrophic factor and risk of atrial fibrillation. PG - 69-73 LID - 10.1016/j.ahj.2016.07.027 [doi] AB - Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study. METHODS: We studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF. RESULTS: We studied 3,457 participants (mean age 65+/-11years, 58% women). During follow-up, 395 participants developed AF. In unadjusted analysis, higher mean serum BDNF concentration was associated with lower incidence of AF (hazard ratio 0.89 per SD, 95% CI 0.80-0.99). In multivariable-adjusted analyses, serum BDNF concentration was not significantly associated with incident AF (hazard ratio 0.98 per SD, 95% CI 0.88-1.09). Compared with the lowest quartile, BDNF levels in the other quartiles were not associated with risk of AF in multivariable-adjusted analyses. No interactions between sex or age with serum BDNF concentrations and risk of AF were found. CONCLUSIONS: In our prospective, community-based sample, we did not find a statistically significant association of serum BDNF levels with risk of incident AF. CI - Copyright (c) 2016 Elsevier Inc. All rights reserved. FAU - Rahman, Faisal AU - Rahman F AD - Department of Medicine, Boston University Medical Center, Boston, MA, USA. FAU - Himali, Jayandra J AU - Himali JJ AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. FAU - Yin, Xiaoyan AU - Yin X AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Department of Biostatistics, Boston University, Boston, MA, USA. AD - Section of Cardiovascular Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. FAU - Beiser, Alexa S AU - Beiser AS AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Biostatistics, Boston University, Boston, MA, USA. FAU - Ellinor, Patrick T AU - Ellinor PT AD - Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA. FAU - Lubitz, Steven A AU - Lubitz SA AD - Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA. FAU - Vasan, Ramachandran S AU - Vasan RS AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Section of Cardiovascular Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. AD - Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. FAU - Magnani, Jared W AU - Magnani JW AD - Department of Medicine, Division of Cardiology, UPMC Heart & Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - McManus, David D AU - McManus DD AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Departments of Medicine and Quantitative Health Sciences, University of Massachusetts, Worcester, MA, USA. AD - Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA. FAU - Seshadri, Sudha AU - Seshadri S AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. FAU - Benjamin, Emelia J AU - Benjamin EJ AD - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. AD - Section of Cardiovascular Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. AD - Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. LA - eng GR - P50 HL120163/HL/NHLBI NIH HHS/United States GR - R01 NS017950/NS/NINDS NIH HHS/United States GR - R01 HL092577/HL/NHLBI NIH HHS/United States GR - 2014105/DDCF_/Doris Duke Charitable Foundation/United States GR - 2015084/DDCF_/Doris Duke Charitable Foundation/United States GR - R01 HL128914/HL/NHLBI NIH HHS/United States GR - P30 AG010129/AG/NIA NIH HHS/United States GR - K23 HL114724/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20161017 PL - United States TA - Am Heart J JT - American heart journal JID - 0370465 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Aged MH - Atrial Fibrillation/*blood MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Proportional Hazards Models MH - Prospective Studies MH - Risk Factors PMC - PMC5166602 MID - NIHMS823541 EDAT- 2016/12/17 06:00 MHDA- 2017/05/26 06:00 PMCR- 2018/01/01 CRDT- 2016/12/17 06:00 PHST- 2016/05/10 00:00 [received] PHST- 2016/07/18 00:00 [accepted] PHST- 2016/12/17 06:00 [entrez] PHST- 2016/12/17 06:00 [pubmed] PHST- 2017/05/26 06:00 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - S0002-8703(16)30229-0 [pii] AID - 10.1016/j.ahj.2016.07.027 [doi] PST - ppublish SO - Am Heart J. 2017 Jan;183:69-73. doi: 10.1016/j.ahj.2016.07.027. Epub 2016 Oct 17.