PMID- 27979675
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20181202
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 70
IP  - 2
DP  - 2017 Aug
TI  - Temporal change of myocardial tissue character is associated with left 
      ventricular reverse remodeling in patients with dilated cardiomyopathy: A 
      cardiovascular magnetic resonance study.
PG  - 185-191
LID - S0914-5087(16)30292-1 [pii]
LID - 10.1016/j.jjcc.2016.10.017 [doi]
AB  - BACKGROUND: Prognostic significance of temporal change in myocardial tissue 
      characterization by cardiovascular magnetic resonance (CMR) has not been 
      elucidated in patients with non-ischemic dilated cardiomyopathy (DCM). METHODS 
      AND RESULTS: Sixty-eight patients with newly-diagnosed DCM who underwent CMR 
      including late gadolinium enhancement (LGE) both at baseline and during follow-up 
      period were enrolled. LGE score was defined by a signal intensity of >/=5 standard 
      deviations above the remote reference myocardium mean. Left ventricular reverse 
      remodeling (LVRR) defined as a LV ejection fraction increase of >/=10% and a 
      decrease in indexed LV end-diastolic diameter of >/=10% compared to those at 
      baseline was detected in 38% of the patients. There was no significant difference 
      in LGE score between baseline and follow-up (5.8% vs. 7.3%; p=0.38). The change 
      in LGE area (delta-LGE) was significantly lower in patients with LVRR than those 
      without (-0.5%+/-3.4% vs. 3.0+/-7.4%; p=0.02). On the other hand, T2 ratio during the 
      follow-up significantly reduced (1.95+/-0.48 vs. 1.67+/-0.56; p<0.01); however, there 
      was no significant difference in the change in T2 ratio between patients with 
      LVRR and those without (-0.29+/-0.73 vs. -0.27+/-0.66; p=0.88). Multivariate logistic 
      analysis indicated that baseline LGE score [odds ratio; 0.78; 95% confidence 
      interval (CI) 0.66 to 0.90; p<0.01] together with delta-LGE (odds ratio; 0.77; 
      95% CI 0.61 to 0.92; p=0.01) were independently associated with subsequent LVRR 
      (p<0.01). CONCLUSIONS: The temporal change of LGE-CMR score during the clinical 
      course was significantly correlated with following LVRR.
CI  - Copyright (c) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Nabeta, Takeru
AU  - Nabeta T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Inomata, Takayuki
AU  - Inomata T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan. Electronic address: inotaka@med.kitasato-u.ac.jp.
FAU - Fujita, Teppei
AU  - Fujita T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Iida, Yuichiro
AU  - Iida Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Ikeda, Yuki
AU  - Ikeda Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Sato, Takanori
AU  - Sato T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Ishii, Shunsuke
AU  - Ishii S
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Maekawa, Emi
AU  - Maekawa E
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Mizutani, Tomohiro
AU  - Mizutani T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Naruke, Takashi
AU  - Naruke T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Koitabashi, Toshimi
AU  - Koitabashi T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Inoue, Yusuke
AU  - Inoue Y
AD  - Department of Diagnostic Radiology, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Ako, Junya
AU  - Ako J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161213
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/pathology/physiopathology
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Heart/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardium/pathology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - Dilated cardiomyopathy
OT  - Left ventricular reverse remodeling
OT  - Magnetic resonance imaging
OT  - Myocardial tissue characterization
EDAT- 2016/12/17 06:00
MHDA- 2017/12/13 06:00
CRDT- 2016/12/17 06:00
PHST- 2016/06/23 00:00 [received]
PHST- 2016/10/05 00:00 [revised]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2016/12/17 06:00 [entrez]
AID - S0914-5087(16)30292-1 [pii]
AID - 10.1016/j.jjcc.2016.10.017 [doi]
PST - ppublish
SO  - J Cardiol. 2017 Aug;70(2):185-191. doi: 10.1016/j.jjcc.2016.10.017. Epub 2016 Dec 
      13.