PMID- 27981267
OWN - NLM
STAT- MEDLINE
DCOM- 20180207
LR  - 20210227
IS  - 1936-7163 (Electronic)
IS  - 0033-6572 (Linking)
VI  - 48
IP  - 2
DP  - 2017
TI  - Unusual maxillary osteoblastic and osteolytic lesions presenting as an initial 
      manifestation of childhood acute myeloid leukemia: A case report.
PG  - 149-153
LID - 10.3290/j.qi.a37383 [doi]
AB  - Changes in facial bones may represent a manifestation of systemic disease. 
      Dentists play an important role in the early detection of these manifestations of 
      complex systemic diseases. A case of unusual maxillary mixed (osteoblastic and 
      osteolytic) lesions as an initial manifestation of childhood acute myeloid 
      leukemia (AML) is presented. A 12-year-old male patient was referred to the 
      Department of Oral Medicine complaining of severe swelling in the right buccal 
      region. 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed 
      tomography (CT) showed enhanced FDG uptake in the right maxillary sinus. In 
      addition, PET maximum intensity projection image showed diffused FDG uptake in 
      the entire bone marrow. Bone marrow aspiration was performed on the lumbar 
      vertebra, and fluorescence in situ hybridization (FISH) demonstrated AML. The 
      patient was diagnosed with AML (M5a) and treated with chemotherapy by the 
      pediatric department. Six months later, the patient achieved complete remission. 
      After chemotherapy, the disappearance of the osteoblastic and osteolytic lesion 
      and 18F-FDG accumulation were confirmed by PET/CT. Dentists should be familiar 
      with oral manifestations of leukemia because early detection of oral lesions 
      would increase the life span of the patients and reduce the severity of 
      complications.
FAU - Shimizu, Rikuka
AU  - Shimizu R
FAU - Ohga, Noritaka
AU  - Ohga N
FAU - Miyakoshi, Masaaki
AU  - Miyakoshi M
FAU - Asaka, Takuya
AU  - Asaka T
FAU - Sato, Jun
AU  - Sato J
FAU - Kitagawa, Yoshimasa
AU  - Kitagawa Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Quintessence Int
JT  - Quintessence international (Berlin, Germany : 1985)
JID - 0342677
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
MH  - Child
MH  - Diagnosis, Differential
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*diagnosis/*drug therapy
MH  - Male
MH  - Maxillary Neoplasms/*diagnosis/*drug therapy
MH  - Positron Emission Tomography Computed Tomography
MH  - Radiopharmaceuticals
EDAT- 2016/12/17 06:00
MHDA- 2018/02/08 06:00
CRDT- 2016/12/17 06:00
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2018/02/08 06:00 [medline]
PHST- 2016/12/17 06:00 [entrez]
AID - 841004 [pii]
AID - 10.3290/j.qi.a37383 [doi]
PST - ppublish
SO  - Quintessence Int. 2017;48(2):149-153. doi: 10.3290/j.qi.a37383.