PMID- 27981275
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20181023
IS  - 2066-8643 (Electronic)
IS  - 1844-4172 (Linking)
VI  - 18
IP  - 4
DP  - 2016 Dec 5
TI  - The impact of microbubble-enhanced therapeutic ultrasound combined with 
      prothrombin on microwave ablation in the rabbit liver.
PG  - 438-445
LID - 10.11152/mu-869 [doi]
AB  - AIM: This study aimed to investigate the effect of microbubble-enhanced 
      ultrasound (MEUS) combined with prothrombin on regional hepatic circulation and 
      microwave ablation (MWA) in rabbit livers. MATERIALS AND METHODS: 
      High-pressureamplitude therapeutic ultrasound (TUS) was used to treat 52 
      surgically exposed livers of healthy New Zealand rabbits: 13 livers were treated 
      with MEUS alone, 13 with MEUS and prothrombin (PMEUS), 13 with ultrasound plus 
      normal saline and 13 with ultrasound plus prothrombin as controls. 
      Contrast-enhanced ultrasound (CEUS) imaging was performed on the exposed livers 
      before and after treatment, and acoustic quantification was done to assess liver 
      perfusion. Then, the liver was divided into two parts, one was used for 
      pathologic examination and the other was ablated with microwave (MWA) and then 
      processedfor pathologic examination. RESULTS: The CEUS images and Peak value 
      after treatment in the PMEUS group were significantly reduced as compared to the 
      remaining 3 groups (p<0.05). Occasional piecemeal hemorrhage was evidenced in the 
      pathological examination in the MEUS group. Obvious cellular degeneration and 
      necrosis with thrombosis were observed in the PMEUS group. Electron microscopy 
      showed endothelial damage in both the MEUS group and PMEUS group. After MWA, 
      coagulated volumes (V) in the PMEUS group were larger than in the remaining 3 
      groups (p<0.05). The cell ultrastructure disorder wasmore severe in the PMEUS 
      group than in remaining 3 groups. CONCLUSION: PMEUS promotes endothelial injury 
      and produces more obvious thrombotic occlusion, improving the therapeutic effect 
      of MWA on the rabbit liver.
FAU - Shi, Ying
AU  - Shi Y
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Department of Ultrasound, the Second Hospital of Shanxi Medical 
      University, Taiyuan, China.
FAU - Liu, Xinyue
AU  - Liu X
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Luo, Zhenli
AU  - Luo Z
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Gu, Fen
AU  - Gu F
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - He, Jianguo
AU  - He J
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Yan, Ping
AU  - Yan P
AD  - Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan, China.
FAU - Zhang, Junwang
AU  - Zhang J
AD  - Department of Gastroenterology, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Zhou, Xiaodong
AU  - Zhou X
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China. zhouxd1@sina.com.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Med Ultrason
JT  - Medical ultrasonography
JID - 101522985
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - 9001-26-7 (Prothrombin)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Animals
MH  - Catheter Ablation/*methods
MH  - Combined Modality Therapy/methods
MH  - Liver/blood supply/*drug effects/pathology/*surgery
MH  - Liver Circulation/drug effects/radiation effects
MH  - Microwaves/therapeutic use
MH  - Phospholipids/*therapeutic use
MH  - Prothrombin/*administration & dosage
MH  - Rabbits
MH  - Sulfur Hexafluoride/*therapeutic use
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/*methods
EDAT- 2016/12/17 06:00
MHDA- 2017/08/19 06:00
CRDT- 2016/12/17 06:00
PHST- 2016/12/17 06:00 [entrez]
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
AID - 10.11152/mu-869 [doi]
PST - ppublish
SO  - Med Ultrason. 2016 Dec 5;18(4):438-445. doi: 10.11152/mu-869.