PMID- 27982014
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20221109
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 7
DP  - 2016 Dec 16
TI  - Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate 
      psoriasis-like inflammation.
PG  - 13581
LID - 10.1038/ncomms13581 [doi]
LID - 13581
AB  - Dendritic cells (DCs) have been implicated in the pathogenesis of psoriasis but 
      the roles for specific DC subsets are not well defined. Here we show that DCs are 
      required for psoriasis-like changes in mouse skin induced by the local injection 
      of IL-23. However, Flt3L-dependent DCs and resident Langerhans cells are 
      dispensable for the inflammation. In epidermis and dermis, the critical DCs are 
      TNF-producing and IL-1beta-producing monocyte-derived DCs, including a population of 
      inflammatory Langerhans cells. Depleting Ly6C(hi) blood monocytes reduces DC 
      accumulation and the skin changes induced either by injecting IL-23 or by 
      application of the TLR7 agonist imiquimod. Moreover, we find that IL-23-induced 
      inflammation requires expression of CCR6 by DCs or their precursors, and that 
      CCR6 mediates monocyte trafficking into inflamed skin. Collectively, our results 
      imply that monocyte-derived cells are critical contributors to psoriasis through 
      production of inflammatory cytokines that augment the activation of skin T cells.
FAU - Singh, Tej Pratap
AU  - Singh TP
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Zhang, Howard H
AU  - Zhang HH
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Borek, Izabela
AU  - Borek I
AD  - Institute of Pathophysiology and Immunology, Medical University of Graz, 8010 
      Graz, Austria.
FAU - Wolf, Peter
AU  - Wolf P
AD  - Department of Dermatology, Medical University of Graz, A-8036 Graz, Austria.
FAU - Hedrick, Michael N
AU  - Hedrick MN
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Singh, Satya P
AU  - Singh SP
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Kelsall, Brian L
AU  - Kelsall BL
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Clausen, Bjorn E
AU  - Clausen BE
AD  - Institute for Molecular Medicine, University Medical Center of the Johannes 
      Gutenberg-University Mainz, 55131 Mainz, Germany.
FAU - Farber, Joshua M
AU  - Farber JM
AD  - Laboratory of Molecular Immunology, National Institute of Allergy and Infectious 
      Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161216
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Aminoquinolines)
RN  - 0 (Interleukin-23)
RN  - 0 (Membrane Proteins)
RN  - 0 (flt3 ligand protein)
RN  - P1QW714R7M (Imiquimod)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage/pharmacology
MH  - Aminoquinolines/administration & dosage/pharmacology
MH  - Animals
MH  - Dendritic Cells/*physiology
MH  - Drug Eruptions
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Imiquimod
MH  - Inflammation/*chemically induced
MH  - Interleukin-23/administration & dosage/pharmacology
MH  - Langerhans Cells/classification/*physiology
MH  - Major Histocompatibility Complex
MH  - Membrane Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Monocytes/*physiology
MH  - Psoriasis/*pathology
MH  - Skin/*cytology
PMC - PMC5171657
EDAT- 2016/12/17 06:00
MHDA- 2018/09/01 06:00
PMCR- 2016/12/16
CRDT- 2016/12/17 06:00
PHST- 2016/05/25 00:00 [received]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/12/17 06:00 [entrez]
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2016/12/16 00:00 [pmc-release]
AID - ncomms13581 [pii]
AID - 10.1038/ncomms13581 [doi]
PST - epublish
SO  - Nat Commun. 2016 Dec 16;7:13581. doi: 10.1038/ncomms13581.