PMID- 27982479
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20200225
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Print)
IS  - 0730-2312 (Linking)
VI  - 118
IP  - 8
DP  - 2017 Aug
TI  - Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy.
PG  - 2108-2117
LID - 10.1002/jcb.25841 [doi]
AB  - A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), 
      that causes oxidative stress, inflammation, and matrix degradation, which leads 
      to multi-pathology in different organs. Although, it is well known that 
      hypermethylation leads to overall gene silencing and hypomethylation leads to 
      overall gene activation, the role of such process in skeletal muscle dysfunction 
      during HHcy condition is unclear. In this study, we emphasized the multiple 
      mechanisms including epigenetic alteration by which HHcy causes skeletal muscle 
      myopathy. This review also highlights possible role of methylation, histone 
      modification, and RNA interference in skeletal muscle dysfunction during HHcy 
      condition and potential therapeutic molecules, putative challenges, and 
      methodologies to deal with HHcy mediated skeletal muscle dysfunction. We also 
      highlighted that B vitamins (mainly B12 and B6), with folic acid supplementation, 
      could be useful as an adjuvant therapy to reverse these consequences associated 
      with this HHcy conditions in skeletal muscle. However, we would recommend to 
      further study involving long-term trials could help to assess efficacy of the use 
      of these therapeutic agents. J. Cell. Biochem. 118: 2108-2117, 2017. (c) 2017 Wiley 
      Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Majumder, Avisek
AU  - Majumder A
AD  - Department of Biochemistry and Molecular Genetics, School of Medicine, University 
      of Louisville, Louisville, Kentucky, 40202.
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky, 40202.
FAU - Behera, Jyotirmaya
AU  - Behera J
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky, 40202.
FAU - Jeremic, Nevena
AU  - Jeremic N
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky, 40202.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Department of Biochemistry and Molecular Genetics, School of Medicine, University 
      of Louisville, Louisville, Kentucky, 40202.
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky, 40202.
LA  - eng
GR  - R01 AR071789/AR/NIAMS NIH HHS/United States
GR  - R01 HL074185/HL/NHLBI NIH HHS/United States
GR  - R01 HL139047/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20170421
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Histones)
RN  - 0 (Thiazolidinediones)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 8059-24-3 (Vitamin B 6)
RN  - 9100L32L2N (Metformin)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Animals
MH  - DNA Methylation/drug effects
MH  - *Epigenesis, Genetic
MH  - Folic Acid/administration & dosage
MH  - Histones/genetics/metabolism
MH  - Homocysteine/metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*diagnosis/drug therapy/genetics/metabolism
MH  - Metformin/therapeutic use
MH  - Muscle, Skeletal/drug effects/*metabolism/pathology
MH  - Muscular Diseases/*diagnosis/drug therapy/genetics/metabolism
MH  - Oxidative Stress
MH  - RNA Interference
MH  - Thiazolidinediones/therapeutic use
MH  - Vitamin B 12/*administration & dosage
MH  - Vitamin B 6/*administration & dosage
PMC - PMC6563903
MID - NIHMS1030774
OTO - NOTNLM
OT  - ECM REMODELING
OT  - HOMOCYSTEINE
OT  - HYPERMETHYLATION
OT  - MUSCLE DYSFUNCTION
OT  - OXIDATIVE STRESS
EDAT- 2016/12/17 06:00
MHDA- 2017/11/03 06:00
PMCR- 2019/06/13
CRDT- 2016/12/17 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2016/12/14 00:00 [accepted]
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2016/12/17 06:00 [entrez]
PHST- 2019/06/13 00:00 [pmc-release]
AID - 10.1002/jcb.25841 [doi]
PST - ppublish
SO  - J Cell Biochem. 2017 Aug;118(8):2108-2117. doi: 10.1002/jcb.25841. Epub 2017 Apr 
      21.