PMID- 27983981
OWN - NLM
STAT- MEDLINE
DCOM- 20170529
LR  - 20220318
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 480
IP  - 4
DP  - 2016 Nov 25
TI  - CUL4A functions as an oncogene in ovarian cancer and is directly regulated by 
      miR-494.
PG  - 675-681
LID - S0006-291X(16)31801-0 [pii]
LID - 10.1016/j.bbrc.2016.10.114 [doi]
AB  - Cullin 4A (CUL4A), as a well-defined oncogene, has been reported to be 
      upregulated in ovarian cancer clinically. However, the biological functions of 
      CUL4A and the molecular mechanism underlying its upregulation in ovarian cancer 
      remains unknown throughly. Here, we show that expression of CUL4A is 
      significantly higher in ovarian cancer tissues compared to corresponding 
      non-cancerous tissues. Moreover, silencing of CUL4A by siRNA markedly inhibits 
      cell proliferation, invasion and epithelial-mesenchymal transition (EMT). We 
      identified CUL4A as a novel target gene of miR-494. Further investigations showed 
      that miR-494 was remarkably downregulated and correlated with poor prognosis in 
      ovarian cancer. Overexpression of miR-494 inhibited proliferation, migration, 
      invasion and EMT of ovarian cancer cells by directly suppressing CUL4A 
      expression. Therefore, our findings indicate that miR-494/CUL4A axis is important 
      in the control of ovarian cancer tumorigenesis.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Han, Xiaoni
AU  - Han X
AD  - Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of 
      Nanchang University, Nanchang, 330003, Jiangxi Province, China.
FAU - Fang, Ziling
AU  - Fang Z
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, 330006, Jiangxi Province, China.
FAU - Wang, Heng
AU  - Wang H
AD  - Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China.
FAU - Jiao, Rongfang
AU  - Jiao R
AD  - Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of 
      Nanchang University, Nanchang, 330003, Jiangxi Province, China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of 
      Nanchang University, Nanchang, 330003, Jiangxi Province, China.
FAU - Fang, Nian
AU  - Fang N
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Nanchang 
      University, Nanchang, 330003, Jiangxi Province, China. Electronic address: 
      fnian3893@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161027
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CUL4A protein, human)
RN  - 0 (Cullin Proteins)
RN  - 0 (MIRN494 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Cell Proliferation/genetics
MH  - China/epidemiology
MH  - Cullin Proteins/*genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Neoplasm Invasiveness/genetics
MH  - Oncogenes/*genetics
MH  - Ovarian Neoplasms/*genetics/*mortality/pathology
MH  - Prevalence
MH  - Risk Factors
MH  - Survival Rate
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - CUL4A
OT  - Invasion
OT  - Ovarian cancer
OT  - Proliferation
OT  - miR-494
EDAT- 2016/12/17 06:00
MHDA- 2017/05/30 06:00
CRDT- 2016/12/17 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2017/05/30 06:00 [medline]
PHST- 2016/12/17 06:00 [entrez]
AID - S0006-291X(16)31801-0 [pii]
AID - 10.1016/j.bbrc.2016.10.114 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2016 Nov 25;480(4):675-681. doi: 
      10.1016/j.bbrc.2016.10.114. Epub 2016 Oct 27.