PMID- 27984624 OWN - NLM STAT- MEDLINE DCOM- 20170710 LR - 20170713 IS - 1003-9406 (Print) IS - 1003-9406 (Linking) VI - 33 IP - 6 DP - 2016 Dec 10 TI - [Progress in research on genetic polymorphisms and sequence-based typing of KIR genes]. PG - 867-870 AB - Killer cell immunoglobulin-like receptors (KIRs) are members of the immunoglobulin superfamily expressed on natural killer (NK) cells and a subset of T cells. Given the receptor-ligand relationship between certain KIR and human leukocyte antigen (HLA) classâ… molecules, the KIRs are involved in the regulation of NK cell activation through conveying activating or inhibitory signals, which plays an important role in immunities involved in transplantation, tumor, infection as well as autoimmune diseases. This paper has provided a review for the research on KIR gene polymorphisms and summarized the characteristics of the sequence-based typing method for KIR genes. FAU - Zhen, Jianxin AU - Zhen J AD - Shenzhen Blood Center, Shenzhen, Guangdong 518035, China. zhihui_deng@aliyun.com. FAU - Yu, Qiong AU - Yu Q LA - chi PT - Journal Article PT - Review PL - China TA - Zhonghua Yi Xue Yi Chuan Xue Za Zhi JT - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JID - 9425197 RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Receptors, KIR) SB - IM MH - HLA Antigens/genetics MH - Histocompatibility Antigens Class I/*genetics MH - Humans MH - Killer Cells, Natural/metabolism MH - Polymorphism, Genetic/*genetics MH - Receptors, KIR/*genetics EDAT- 2016/12/17 06:00 MHDA- 2017/07/14 06:00 CRDT- 2016/12/17 06:00 PHST- 2016/12/17 06:00 [entrez] PHST- 2016/12/17 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] AID - 940633181 [pii] AID - 10.3760/cma.j.issn.1003-9406.2016.06.027 [doi] PST - ppublish SO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Dec 10;33(6):867-870. doi: 10.3760/cma.j.issn.1003-9406.2016.06.027.