PMID- 27984840
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20221207
IS  - 1098-8785 (Electronic)
IS  - 0735-1631 (Linking)
VI  - 34
IP  - 7
DP  - 2017 Jun
TI  - Glycemic Control and Pregnancy Outcomes in Women with Type 2 Diabetes Treated 
      with Oral Hypoglycemic Agents.
PG  - 697-704
LID - 10.1055/s-0036-1597625 [doi]
AB  - Objective There is limited data regarding the use of oral hypoglycemic agents 
      (OHAs) in pregnant women with type 2 diabetes mellitus (T2DM). Study Design This 
      was a retrospective cohort study of women with T2DM who were treated with OHA or 
      insulin from the first trimester onward. Bivariate and multivariate logistic 
      regression analyses were used to compare pregnancy outcomes in women treated with 
      OHA to those treated with insulin. Results One-third (67/198) of women were 
      treated with OHA. Women treated with OHA had a shorter disease duration (4.4 vs. 
      6.8 years; p = 0.001), were more likely to have a normal prepregnancy body mass 
      index, and had less gestational weight gain (GWG; 22.4 vs. 30.4 lbs; p = 0.005). 
      A lower GWG was noted in obese women treated with OHA (19.9 +/- 18.6 vs. 
      28.3 +/- 17.7 pounds; p = 0.008). First-trimester hemoglobin A1c values were lower 
      with OHAs, but second- and third-trimester values were similar. Among women who 
      started pregnancy using OHA, 37/67 (55.2%) remained on OHA at delivery. Pregnancy 
      outcomes did not differ between women who received OHA and those treated with 
      insulin. Conclusion OHA treatment is more likely in women with T2DM who begin 
      pregnancy with less severe disease, and use of OHA may be associated with 
      decreased GWG.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Feghali, Maisa N
AU  - Feghali MN
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens 
      Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
FAU - Caritis, Steve N
AU  - Caritis SN
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens 
      Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
FAU - Catov, Janet M
AU  - Catov JM
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens 
      Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
FAU - Scifres, Christina M
AU  - Scifres CM
AD  - Department of Obstetrics and Gynecology, University of Oklahoma College of 
      Medicine, Oklahoma City, Oklahoma.
LA  - eng
GR  - KL2 TR001856/TR/NCATS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161216
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Cesarean Section/statistics & numerical data
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Fetal Macrosomia/*epidemiology/etiology
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Infant, Newborn
MH  - Insulin/*therapeutic use
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Pennsylvania/epidemiology
MH  - Pregnancy
MH  - Pregnancy Outcome/*epidemiology
MH  - Pregnancy in Diabetics/*drug therapy
MH  - Retrospective Studies
MH  - Weight Gain/drug effects
EDAT- 2016/12/17 06:00
MHDA- 2018/03/23 06:00
CRDT- 2016/12/17 06:00
PHST- 2016/12/17 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2016/12/17 06:00 [entrez]
AID - 10.1055/s-0036-1597625 [doi]
PST - ppublish
SO  - Am J Perinatol. 2017 Jun;34(7):697-704. doi: 10.1055/s-0036-1597625. Epub 2016 
      Dec 16.