PMID- 27987791
OWN - NLM
STAT- MEDLINE
DCOM- 20170412
LR  - 20170926
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 71
DP  - 2017 Feb 1
TI  - Antibacterial ability and angiogenic activity of Cu-Ti-O nanotube arrays.
PG  - 93-99
LID - S0928-4931(16)31542-9 [pii]
LID - 10.1016/j.msec.2016.09.077 [doi]
AB  - Bacterial infection and loosening of orthopedic implants remain two disastrously 
      postoperative complications. Angiogenesis is critical important to facilitate 
      implant osseointegration in vivo. TiO(2) nanotubes arrays (NTAs) with proper 
      dimensions possess good osseointegration ability. Accordingly, the present work 
      incorporated copper (Cu) into TiO(2) NTAs (Cu-Ti-O NTAs) to enhance their 
      antibacterial ability and angiogenesis activity, which was realized through 
      anodizing magnetron-sputtered TiCu coatings with different Cu contents on pure 
      titanium (Ti). Our results show ordered Cu-Ti-O NTAs can be produced under proper 
      Cu content (<15.14%) in TiCu coatings. The NTAs possess excellent long-term 
      antibacterial ability against Staphylococcus aureus (S. aureus), which may be 
      ascribed to sustained release of Cu(2+). The cytotoxicity of Cu-Ti-O NTAs to 
      endothelial cells (ECs) could be negligible and can even promote cell 
      proliferation as revealed by live/dead staining and MTT. Meanwhile, Cu-Ti-O NTAs 
      can up-regulate nitric oxide (NO) synthesis and vascular endothelial growth 
      factors (VEGF) secretion of ECs on the sample surfaces compared with that of pure 
      TiO(2) NTAs (control). Furthermore, the angiogenic activity is also enhanced in 
      ionic extracts of Cu-Ti-O NTAs compared with the control. The excellent long-term 
      antibacterial ability and favorable angiogenic activity render Cu-Ti-O NTAs to be 
      promising implant coatings.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Zong, Mingxiang
AU  - Zong M
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Bai, Long
AU  - Bai L
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Liu, Yanlian
AU  - Liu Y
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Zhang, Xiangyu
AU  - Zhang X
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Huang, Xiaobo
AU  - Huang X
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
FAU - Hang, Ruiqiang
AU  - Hang R
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China. Electronic address: hangruiqiang@tyut.edu.cn.
FAU - Tang, Bin
AU  - Tang B
AD  - Research Institute of Surface Engineering, Taiyuan University of Technology, 
      030024 Taiyuan, China.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 789U1901C5 (Copper)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Angiogenesis Inducing Agents/chemistry/pharmacology
MH  - *Anti-Bacterial Agents/chemistry/pharmacology
MH  - Cell Line
MH  - *Copper/chemistry/pharmacology
MH  - Delayed-Action Preparations/chemistry/pharmacology
MH  - Humans
MH  - Nanotubes/*chemistry
MH  - Staphylococcus aureus/*growth & development
MH  - *Titanium/chemistry/pharmacology
OTO - NOTNLM
OT  - Anodization
OT  - Bacteria
OT  - Endothelial cells
OT  - TiO(2) nanotubes
EDAT- 2016/12/19 06:00
MHDA- 2017/04/13 06:00
CRDT- 2016/12/19 06:00
PHST- 2016/05/25 00:00 [received]
PHST- 2016/09/09 00:00 [revised]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2016/12/19 06:00 [entrez]
PHST- 2016/12/19 06:00 [pubmed]
PHST- 2017/04/13 06:00 [medline]
AID - S0928-4931(16)31542-9 [pii]
AID - 10.1016/j.msec.2016.09.077 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:93-99. doi: 
      10.1016/j.msec.2016.09.077. Epub 2016 Sep 30.