PMID- 27988097
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20180303
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Linking)
VI  - 33
IP  - 2
DP  - 2017 Feb
TI  - Parasites Dampen Dendritic Cell Activation to Ensure Their Survival.
PG  - 78-80
LID - S1471-4922(16)30223-9 [pii]
LID - 10.1016/j.pt.2016.12.001 [doi]
AB  - Dendritic cells (DCs) are critical for induction of protective immunity against 
      Leishmania major. However, DC activation occurs only several weeks after parasite 
      transmission. Parasites synthesize a macrophage-inducible C-type lectin (Mincle) 
      ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus 
      delaying induction of interferon-gamma-producing T cells responsible for parasite 
      eradication.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - von Stebut, Esther
AU  - von Stebut E
AD  - Department of Dermatology, University Medical Center, Johannes 
      Gutenberg-University Mainz, Germany. Electronic address: vonstebu@uni-mainz.de.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20161214
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
RN  - 0 (Lectins, C-Type)
RN  - 0 (Ligands)
SB  - IM
CON - Immunity. 2016 Oct 18;45(4):788-801. PMID: 27742545
MH  - Dendritic Cells/*immunology
MH  - Lectins, C-Type/metabolism
MH  - Leishmania/immunology/*physiology
MH  - Leishmaniasis/*immunology/*parasitology/transmission
MH  - Ligands
MH  - T-Lymphocytes/immunology/parasitology
EDAT- 2016/12/19 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/12/19 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2016/12/01 00:00 [accepted]
PHST- 2016/12/19 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/12/19 06:00 [entrez]
AID - S1471-4922(16)30223-9 [pii]
AID - 10.1016/j.pt.2016.12.001 [doi]
PST - ppublish
SO  - Trends Parasitol. 2017 Feb;33(2):78-80. doi: 10.1016/j.pt.2016.12.001. Epub 2016 
      Dec 14.