PMID- 27988513
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20220317
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 137
IP  - 1
DP  - 2017
TI  - Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics 
      in Patients with ST Segment Elevation Myocardial Infarction.
PG  - 27-35
LID - 10.1159/000452705 [doi]
AB  - OBJECTIVES: To compare angiographic and optical coherence tomography (OCT) data 
      pertinent to thrombi, along with the histologic characteristics of aspirated 
      thrombi in patients presenting with ST elevation myocardial infarction (STEMI) 
      with or without inflammation, as assessed by C-reactive protein (CRP) and 
      myeloperoxidase (MPO). METHODS: In the OCTAVIA (Optical Coherence Tomography 
      Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with 
      STEMI referred for primary percutaneous intervention were enrolled. The patients 
      underwent OCT assessment of the culprit vessel, along with blood sampling of CRP 
      and MPO, and histologic analysis of the thrombus. RESULTS: Biomarkers were 
      available for 129 patients, and histology and immunohistochemistry of the thrombi 
      were available for 78 patients. Comparisons were made using the median thresholds 
      of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no 
      correlation between CRP and MPO levels in the whole population (p = 0.685). 
      Patients with high CRP levels had higher thrombus grades and more frequent TIMI 
      flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 
      5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5%, p = 0.04, respectively). 
      Patients with high MPO levels more commonly had early thrombi than had those with 
      low MPO levels (42.5 vs. 20.0%, p = 0.04). CONCLUSIONS: CRP and MPO were not 
      correlated in STEMI patients, possibly reflecting different pathogenic 
      mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Niccoli, Giampaolo
AU  - Niccoli G
AD  - Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
FAU - Menozzi, Alberto
AU  - Menozzi A
FAU - Capodanno, Davide
AU  - Capodanno D
FAU - Trani, Carlo
AU  - Trani C
FAU - Sirbu, Vasile
AU  - Sirbu V
FAU - Fineschi, Massimo
AU  - Fineschi M
FAU - Zara, Chiara
AU  - Zara C
FAU - Crea, Filippo
AU  - Crea F
FAU - Trabattoni, Daniela
AU  - Trabattoni D
FAU - Saia, Francesco
AU  - Saia F
FAU - Ladich, Elena
AU  - Ladich E
FAU - Biondi Zoccai, Giuseppe
AU  - Biondi Zoccai G
FAU - Attizzani, Guilherme
AU  - Attizzani G
FAU - Guagliumi, Giulio
AU  - Guagliumi G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20161217
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Coronary Angiography
MH  - Coronary Thrombosis/*blood/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Peroxidase/*blood
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/etiology/*surgery
MH  - Tomography, Optical Coherence
EDAT- 2016/12/19 06:00
MHDA- 2018/08/14 06:00
CRDT- 2016/12/19 06:00
PHST- 2016/02/24 00:00 [received]
PHST- 2016/10/19 00:00 [accepted]
PHST- 2016/12/19 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2016/12/19 06:00 [entrez]
AID - 000452705 [pii]
AID - 10.1159/000452705 [doi]
PST - ppublish
SO  - Cardiology. 2017;137(1):27-35. doi: 10.1159/000452705. Epub 2016 Dec 17.