PMID- 27989511
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20170906
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 27
IP  - 3
DP  - 2017 Mar
TI  - Increment of serum bilirubin as an independent marker predicting new-onset type 2 
      diabetes mellitus in a Korean population.
PG  - 234-240
LID - S0939-4753(15)30265-9 [pii]
LID - 10.1016/j.numecd.2016.10.003 [doi]
AB  - BACKGROUND AND AIMS: Several cross-sectional studies reported that serum 
      bilirubin concentrations had an inverse association with type 2 diabetes mellitus 
      (T2DM) prevalence. The aim of the current study was to investigate the 
      relationship between percentage change in bilirubin levels (PCB) and incident 
      risk of T2DM using a longitudinal model. METHODS AND RESULTS: 22,084 participants 
      who received regular health check-ups between 2006 and 2012 were enrolled. 
      Multivariable-adjusted Cox regression models were used to determine the hazard 
      ratio (HR) of incident T2DM based on PCB. PCB was determined by subtracting 
      baseline serum bilirubin level (BB) from the bilirubin level at the end of 
      follow-up or a year before the last date of diagnosis, dividing by BB and 
      multiplying by 100. Compared to non-diabetics, BB was lower in the diabetic group 
      at the initial visit. There were 20,098 participants without T2DM at the initial 
      visit; 1253 new cases occurred during follow-up. As PCB increased, T2DM incidence 
      also increased (P < 0.001). After adjusting for confounders, the HR of incident 
      T2DM in the highest PCB quartile was 2.08 (95% confidence interval [CI] 
      1.76-2.46). This trend remained significant when PCB was analyzed as a continuous 
      variable (HR for 1-SD increment, 1.25; 95% CI 1.19-1.31). Additional analysis 
      comparing the rate of PCB during the follow-up period revealed that the serum 
      bilirubin level of the Incident T2DM group increased before T2DM development and 
      decreased rapidly thereafter compared to others (P < 0.001). CONCLUSIONS: 
      Bilirubin level increment over time is associated with T2DM development.
CI  - Copyright (c) 2016 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Lee, S-E
AU  - Lee SE
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Lee, Y-B
AU  - Lee YB
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Jun, J E
AU  - Jun JE
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Jin, S-M
AU  - Jin SM
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Jee, J H
AU  - Jee JH
AD  - Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Republic of Korea.
FAU - Bae, J C
AU  - Bae JC
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung 
      Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic 
      of Korea.
FAU - Kim, J H
AU  - Kim JH
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 
      Electronic address: jaehyeonkim26@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20161022
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adult
MH  - Bilirubin/*blood
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Seoul/epidemiology
MH  - Time Factors
OTO - NOTNLM
OT  - Bilirubin
OT  - Diabetes mellitus, type 2
OT  - Heme oxygenase-1
EDAT- 2016/12/19 06:00
MHDA- 2017/09/07 06:00
CRDT- 2016/12/20 06:00
PHST- 2015/10/12 00:00 [received]
PHST- 2016/07/31 00:00 [revised]
PHST- 2016/10/11 00:00 [accepted]
PHST- 2016/12/19 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2016/12/20 06:00 [entrez]
AID - S0939-4753(15)30265-9 [pii]
AID - 10.1016/j.numecd.2016.10.003 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2017 Mar;27(3):234-240. doi: 
      10.1016/j.numecd.2016.10.003. Epub 2016 Oct 22.