PMID- 27990369
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 9
IP  - 11
DP  - 2016
TI  - Macular changes of neuromyelitis optica through spectral-domain optical coherence 
      tomography.
PG  - 1638-1645
AB  - AIM: To evaluate the thickness of the retinal layers in the macula using 
      spectral-domain optical coherence tomography (SD-OCT) in patients with 
      neuromyelitis optica (NMO). METHODS: Spectralis SD-OCT, utilizing automated 
      macular layer segmentation, was performed in 26 NMO patients and 26 healthy 
      controls. Visual function including visual field tests and pattern visual evoked 
      potential were recorded in study subjects. RESULTS: Forty-one eyes from 26 NMO 
      patients and 52 eyes from 26 age- and sex-matched healthy controls were included. 
      Besides total macular volume, peri-paipillary retinal nerve fiber layer (RNFL) 
      thickness, the thickness of macular RNFL, ganglion cell layer (GCL) and inner 
      plexiform layer (IPL) were also significantly reduced in NMO patients compared to 
      those inhealthy controls (P<0.000). No differences were found in the thickness of 
      macular inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear 
      layer (ONL) between the two groups. Reversely, the outer retinal layer (ORL) was 
      shown to be thicker in NMO than controls (P<0.05). Compared with the 
      peri-papillary RNFL thickness, the GCL thickness was demonstrated to correlate 
      with visual function better. CONCLUSION: The study provides in vivo evidence of 
      retinal neural loss in NMO patients and demonstrates a better structure-function 
      correlation between retinal ganglion cell and visual function than peri-papillary 
      RNFL does. In addition, no evidence of primary neural damage is found. Besides, 
      the photoreceptor cells and retinal pigments epithelial (RPE) cells presumably 
      proliferated in compensation in NMO after retinal neural loss.
FAU - Cheng, Lu
AU  - Cheng L
AD  - Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Shanghai 
      First People's Hospital, Shanghai 20080, China; Shanghai Key Laboratory of Fundus 
      Disease, Shanghai 20080, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Shanghai 
      First People's Hospital, Shanghai 20080, China; Shanghai Key Laboratory of Fundus 
      Disease, Shanghai 20080, China.
FAU - He, Xu
AU  - He X
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
FAU - Xu, Xun
AU  - Xu X
AD  - Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Shanghai 
      First People's Hospital, Shanghai 20080, China; Shanghai Key Laboratory of Fundus 
      Disease, Shanghai 20080, China.
FAU - Ling, Zhen-Fen
AU  - Ling ZF
AD  - Department of Neurology, Shanghai Jiao Tong University Affiliated Shanghai First 
      People's Hospital, Shanghai 20080, China.
LA  - eng
PT  - Journal Article
DEP - 20161118
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC5145094
OTO - NOTNLM
OT  - ganglion cell loss
OT  - macular layer thickness
OT  - neuromyelitis optica
OT  - optical coherence tomography
EDAT- 2016/12/19 06:00
MHDA- 2016/12/19 06:01
PMCR- 2016/11/18
CRDT- 2016/12/20 06:00
PHST- 2016/09/07 00:00 [received]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/12/20 06:00 [entrez]
PHST- 2016/12/19 06:00 [pubmed]
PHST- 2016/12/19 06:01 [medline]
PHST- 2016/11/18 00:00 [pmc-release]
AID - ijo-09-11-1638 [pii]
AID - 10.18240/ijo.2016.11.17 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2016 Nov 18;9(11):1638-1645. doi: 10.18240/ijo.2016.11.17. 
      eCollection 2016.