PMID- 27993081
OWN - NLM
STAT- MEDLINE
DCOM- 20170608
LR  - 20180724
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 50
IP  - 24
DP  - 2016 Dec 20
TI  - Contribution of Persistent Organic Pollutant Exposure to the Adipose Tissue 
      Oxidative Microenvironment in an Adult Cohort: A Multipollutant Approach.
PG  - 13529-13538
AB  - Despite growing in vitro and in vivo evidence of the putative role of persistent 
      organic pollutants (POPs) in the induction of oxidative damage in cell 
      structures, this issue has been poorly addressed from an epidemiologic 
      perspective. The aim of this study was to explore associations between adipose 
      tissue POP concentrations and the in situ oxidative microenvironment. A 
      cross-sectional study was conducted in a subsample (n = 271) of a previously 
      established cohort, quantifying levels of eight POPs and four groups of oxidative 
      stress biomarkers in adipose tissue. Associations were explored using 
      multivariate linear regression analyses adjusted for potential confounders. We 
      assessed the combined effect of POPs on oxidative stress/glutathione system 
      biomarkers using weighted quantile sum regression (WQS). Increased concentrations 
      of p,p'-DDE, HCB, beta-HCH, dicofol, and PCBs (congeners -138, -153, and -180) were 
      predominantly associated with higher lipid peroxidation (TBARS) [exp(beta) = 
      1.09-1.78, p < 0.01-0.04)] and SOD activity [exp(beta) = 1.13-1.48, p < 0.01-0.05)] 
      levels. However, only a few associations were observed with glutathione system 
      biomarkers, e.g., PCB-180 with total glutathione [exp(beta) = 1.98, p = 0.03]. The 
      WQS index was found to be positively associated with SOD activity, and PCB-138, 
      PCB-180, and beta-HCH were the main contributors to the index. Likewise, the WQS 
      index was positively associated with TBARS levels, with the three PCBs acting as 
      the main contributors. This is the first epidemiological evidence of the putative 
      disruption by POPs of the adipose tissue oxidative microenvironment. Our results 
      indicate that POP exposure may enhance alternative pathways to the glutathione 
      detoxification route, which might result in tissue damage. Further research is 
      warranted to fully elucidate the potential health implications.
FAU - Artacho-Cordon, Francisco
AU  - Artacho-Cordon F
AD  - Radiology and Physical Medicine Department, University of Granada , Granada, 
      18012, Spain.
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
FAU - Leon, Josefa
AU  - Leon J
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
AD  - CIBER en Enfermedades Hepaticas y Digestivas (CIBEREHD) , 28029 Madrid, Spain.
FAU - Saenz, Jose M
AU  - Saenz JM
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
FAU - Fernandez, Mariana F
AU  - Fernandez MF
AD  - Radiology and Physical Medicine Department, University of Granada , Granada, 
      18012, Spain.
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
AD  - CIBER en Epidemiologia y Salud Publica (CIBERESP) , 28029 Madrid, Spain.
FAU - Martin-Olmedo, Piedad
AU  - Martin-Olmedo P
AD  - Escuela Andaluza de Salud Publica , Granada, 18011, Spain.
FAU - Olea, Nicolas
AU  - Olea N
AD  - Radiology and Physical Medicine Department, University of Granada , Granada, 
      18012, Spain.
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
AD  - CIBER en Epidemiologia y Salud Publica (CIBERESP) , 28029 Madrid, Spain.
FAU - Arrebola, Juan P
AU  - Arrebola JP
AUID- ORCID: 0000-0002-8643-2423
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Hospitales Universitarios 
      de Granada , Granada, 18012, Spain.
AD  - Escuela Andaluza de Salud Publica , Granada, 18011, Spain.
AD  - Oncology Unit, Virgen de las Nieves University Hospital , Granada, 18012 Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161205
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adipose Tissue
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Dichlorodiphenyl Dichloroethylene
MH  - *Environmental Pollutants
MH  - Glutathione
MH  - Humans
MH  - *Polychlorinated Biphenyls
EDAT- 2016/12/21 06:00
MHDA- 2017/06/09 06:00
CRDT- 2016/12/21 06:00
PHST- 2016/12/21 06:00 [entrez]
PHST- 2016/12/21 06:00 [pubmed]
PHST- 2017/06/09 06:00 [medline]
AID - 10.1021/acs.est.6b03783 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2016 Dec 20;50(24):13529-13538. doi: 
      10.1021/acs.est.6b03783. Epub 2016 Dec 5.