PMID- 27993394
OWN - NLM
STAT- MEDLINE
DCOM- 20170602
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1480
DP  - 2017 Jan 13
TI  - Monolithic column modified with bifunctional ionic liquid and styrene stationary 
      phases for capillary electrochromatography.
PG  - 99-105
LID - S0021-9673(16)31661-2 [pii]
LID - 10.1016/j.chroma.2016.12.030 [doi]
AB  - A novel monolithic column with ionic liquid and styrene-modified bifunctional 
      group was prepared for capillary electrochromatography (CEC) by in situ 
      copolymerization in a ternary porogenic solvent. Ionic liquid 
      (1-allyl-methylimidazolium chloride, AlMeIm(+)Cl(-)) and styrene served as the 
      bifunctional monomer, while ethylene dimethacrylate (EDMA) was used as the 
      cross-linker. The monomer of AlMeIm(+)Cl(-) was introduced as anion-exchange 
      group, while styrene as hydrophobic and aromatic group; the similar conjugated 
      structure in AlMeIm(+)Cl(-) and styrene was beneficial for offeing obvious 
      synergistic effect. The bifunctional stationary phase possessed powerful 
      selectivity for the separation of neutral compounds, acidic analytes and phenols. 
      The highest column efficiency was 2.70x10(5) platesm(-1) (theoretical plates, N) 
      for toluene. A relatively strong electroosmotic flow (EOF) was obtained in a wide 
      range of pH values from 2.0 to 12.0, which could successfully achieve the rapid 
      separation of the analytes within 10min. The proposed monolithic column was 
      characterized by scanning electron microscopy (SEM) and Fourier transform 
      infrared (FT-IR). The results indicated that the resultant monolithic column had 
      good permeability and excellent mechanical stability. Good reproducibility was 
      obtained with relative standard deviations (RSDs) of the retention time in the 
      range of 0.24-0.47% and 0.81-2.17% for run-to-run (n=5) and day-to-day (n=5), 
      while 1.09-2.70% and 0.98-1.70% for column-to-column (n=3) and batch-to-batch 
      (n=3), respectively. The combination of AlMeIm(+)Cl(-) and styrene was a 
      promising option in the fabrication of the organic polymer monolithic column.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Mao, Zhenkun
AU  - Mao Z
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, 
      China; State Key Laboratory of Transducer Technology, Chinese Academy of 
      Sciences, Beijing 10080, China.
FAU - Chen, Zilin
AU  - Chen Z
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, 
      China; State Key Laboratory of Transducer Technology, Chinese Academy of 
      Sciences, Beijing 10080, China. Electronic address: chenzl@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161214
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Ionic Liquids)
RN  - 0 (Methacrylates)
RN  - 0 (Phenols)
RN  - 0 (Polymers)
RN  - 0 (Solvents)
RN  - 3FPU23BG52 (Toluene)
RN  - 44LJ2U959V (Styrene)
RN  - 7BK5G69305 (ethylene dimethacrylate)
SB  - IM
MH  - Capillary Electrochromatography/*methods
MH  - Electroosmosis
MH  - Hydrogen-Ion Concentration
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Ionic Liquids/*chemistry
MH  - Methacrylates/chemistry
MH  - Microscopy, Electron, Scanning
MH  - Phenols/chemistry/isolation & purification
MH  - Polymers/chemistry
MH  - Reproducibility of Results
MH  - Solvents
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Styrene/*chemistry
MH  - Toluene/chemistry
OTO - NOTNLM
OT  - Bifunctional stationary phase
OT  - Capillary electrochromatography
OT  - Ionic liquid
OT  - Monolithic column
OT  - Styrene
EDAT- 2016/12/21 06:00
MHDA- 2017/06/03 06:00
CRDT- 2016/12/21 06:00
PHST- 2016/09/19 00:00 [received]
PHST- 2016/12/12 00:00 [revised]
PHST- 2016/12/12 00:00 [accepted]
PHST- 2016/12/21 06:00 [pubmed]
PHST- 2017/06/03 06:00 [medline]
PHST- 2016/12/21 06:00 [entrez]
AID - S0021-9673(16)31661-2 [pii]
AID - 10.1016/j.chroma.2016.12.030 [doi]
PST - ppublish
SO  - J Chromatogr A. 2017 Jan 13;1480:99-105. doi: 10.1016/j.chroma.2016.12.030. Epub 
      2016 Dec 14.