PMID- 27994706
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1918-2805 (Print)
IS  - 1918-2813 (Electronic)
IS  - 1918-2805 (Linking)
VI  - 1
IP  - 1
DP  - 2008 Dec
TI  - Increased Plasma Superoxide Radical in Patients with Non-Metastatic Colorectal 
      Cancer.
PG  - 45-48
AB  - BACKGROUND: Several studies have investigated the potential role of oxidative 
      stress in the evolution of colorectal cancer. In most of these studies, oxidative 
      stress was assessed indirectly by measurements of indices like lipid 
      peroxidation, protein oxidation or antioxidant status. The present study was 
      undertaken to directly assess systemic oxidative stress by measuring plasma 
      superoxide radical (O(2)(-).) in patients with non-metastatic colorectal cancer. 
      METHODS: Twelve patients (6 males and 6 females) with a recent diagnosis of 
      colorectal cancer and no signs of metastases and 12 healthy volunteers matched 
      for age and gender were enrolled in the study. O(2)(-). levels in plasma were 
      assessed by application of a new ultra-sensitive fluorescent assay. Also lipid 
      peroxidation levels in plasma were measured as thiobarbituric acid reactive 
      species (TBARS). RESULTS: In the plasma fraction of whole blood, there was a 
      significant increase (47%) of O(2)(-). levels in colorectal carcinoma patients as 
      compared to healthy volunteers (P < 0.001). In fractionated plasma, no O(2)(-). 
      was detected in both groups. Plasma TBARS levels were increased by 81% in 
      colorectal carcinoma patients as compared to controls (P < 0.001). CONCLUSIONS: 
      These data show that colorectal cancer, even at early (non-metastatic) stages, 
      induces systemic oxidative stress as evidenced by increased O(2).(-) levels 
      measured in plasma. Given the important role of oxidative stress in 
      carcinogenesis and the fact that O(2).(-) is considered its primary parameter, 
      our findings if confirmed in larger studies might establish the potential 
      validity of O(2).(-) as a new biomarker for colorectal cancer.
FAU - Assimakopoulos, Stelios F
AU  - Assimakopoulos SF
AD  - Department of Internal Medicine, University Hospital of Patras, Patras 26504, 
      Greece.
FAU - Grintzalis, Konstantinos
AU  - Grintzalis K
AD  - Section of Genetics, Cell and Developmental Biology, Department of Biology, 
      University of Patras, Patras, Greece.
FAU - Papapostolou, Ioannis
AU  - Papapostolou I
AD  - Section of Genetics, Cell and Developmental Biology, Department of Biology, 
      University of Patras, Patras, Greece.
FAU - Thomopoulos, Konstantinos C
AU  - Thomopoulos KC
AD  - Division of Gastroenterology, Department of Internal Medicine, University 
      Hospital of Patras, Patras 26504, Greece.
FAU - Georgiou, Christos D
AU  - Georgiou CD
AD  - Section of Genetics, Cell and Developmental Biology, Department of Biology, 
      University of Patras, Patras, Greece.
LA  - eng
PT  - Journal Article
DEP - 20081120
PL  - Canada
TA  - Gastroenterology Res
JT  - Gastroenterology research
JID - 101519422
PMC - PMC5154215
OTO - NOTNLM
OT  - colorectal cancer
OT  - lipid peroxidation
OT  - oxidative stress
OT  - superoxide radical
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
PMCR- 2008/12/01
CRDT- 2016/12/21 06:00
PHST- 2008/11/24 00:00 [received]
PHST- 2008/11/30 00:00 [accepted]
PHST- 2016/12/21 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 10.4021/gr2008.11.1249 [doi]
PST - ppublish
SO  - Gastroenterology Res. 2008 Dec;1(1):45-48. doi: 10.4021/gr2008.11.1249. Epub 2008 
      Nov 20.