PMID- 27995324
OWN - NLM
STAT- MEDLINE
DCOM- 20190319
LR  - 20190319
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 32
IP  - 10
DP  - 2017 Oct
TI  - HLA epitope matching in pediatric renal transplantation.
PG  - 1861-1869
LID - 10.1007/s00467-016-3557-4 [doi]
AB  - Chronic graft loss due to antibody-mediated rejection (AMR) and the difficulty of 
      re-transplanting highly sensitized patients are two of the major long-term 
      challenges in pediatric renal transplantation. Treatments for AMR are often 
      ineffective and desensitization protocols can be a high risk, making prevention a 
      highly appealing strategy. Insights into the structural determinants of humoral 
      alloantigenicity present an exciting opportunity to reassess our current paradigm 
      of tissue matching and potentially preventing these complications. We review the 
      theory behind human leukocyte antigen (HLA) B cell epitopes and the various 
      systems that have been proposed to define them, including eplets. There is a 
      growing body of clinical evidence suggesting that epitope-based tissue matching 
      may be superior to traditional HLA antigen matching at predicting a range of 
      clinical outcomes. However, additional studies are required to better understand 
      the biological relevance of these systems of defining epitopes and their role in 
      pediatric transplantation.
FAU - Sypek, Matthew P
AU  - Sypek MP
AD  - Department of Nephrology, Royal Children's Hospital, Melbourne, Australia. 
      matthew.sypek@rch.org.au.
AD  - Department of Nephrology, Royal Melbourne Hospital, Melbourne, Australia. 
      matthew.sypek@rch.org.au.
AD  - University of Melbourne, Melbourne, Australia. matthew.sypek@rch.org.au.
FAU - Hughes, Peter
AU  - Hughes P
AD  - Department of Nephrology, Royal Children's Hospital, Melbourne, Australia.
AD  - Department of Nephrology, Royal Melbourne Hospital, Melbourne, Australia.
AD  - University of Melbourne, Melbourne, Australia.
FAU - Kausman, Joshua Y
AU  - Kausman JY
AD  - Department of Nephrology, Royal Children's Hospital, Melbourne, Australia.
AD  - Department of Nephrology, Royal Melbourne Hospital, Melbourne, Australia.
AD  - University of Melbourne, Melbourne, Australia.
AD  - Murdoch Children's Research Institute, Melbourne, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161219
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Epitopes, B-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Child
MH  - Donor Selection/methods
MH  - Epitopes, B-Lymphocyte/*analysis/immunology
MH  - Graft Rejection/immunology/*prevention & control
MH  - HLA Antigens/*analysis/immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Kidney Transplantation/*adverse effects
OTO - NOTNLM
OT  - Donor-specific antibody
OT  - Epitope
OT  - Eplet
OT  - Human leukocyte antigen
OT  - Sensitization
OT  - Transplantation
EDAT- 2016/12/21 06:00
MHDA- 2019/03/20 06:00
CRDT- 2016/12/21 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2016/12/01 00:00 [accepted]
PHST- 2016/11/30 00:00 [revised]
PHST- 2016/12/21 06:00 [pubmed]
PHST- 2019/03/20 06:00 [medline]
PHST- 2016/12/21 06:00 [entrez]
AID - 10.1007/s00467-016-3557-4 [pii]
AID - 10.1007/s00467-016-3557-4 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2017 Oct;32(10):1861-1869. doi: 10.1007/s00467-016-3557-4. Epub 
      2016 Dec 19.