PMID- 27997016
OWN - NLM
STAT- MEDLINE
DCOM- 20180703
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 22
IP  - 4
DP  - 2017 Apr 1
TI  - Optimizing light delivery through fiber bundle in photoacoustic imaging with 
      clinical ultrasound system: Monte Carlo simulation and experimental validation.
PG  - 41008
LID - 10.1117/1.JBO.22.4.041008 [doi]
AB  - Translating photoacoustic (PA) imaging into clinical setup is a challenge. We 
      report an integrated PA and ultrasound imaging system by combining the light 
      delivery to the tissue with the ultrasound probe. First, Monte Carlo simulations 
      were run to study the variation in absorbance within tissue for different angles 
      of illumination, fiber-to-probe distance (FPD), and fiber-to-tissue distance 
      (FTD). This is followed by simulation for different depths of the embedded sphere 
      (object of interest). Several probe holders were designed for different light 
      launching angles. Phantoms were developed to mimic a sentinel lymph node imaging 
      scenario. It was observed that, for shallower imaging depths, the variation in 
      signal-to-noise ratio (SNR) values could be as high as 100% depending on the 
      angle of illumination at a fixed FPD and FTD. Results confirm that different 
      light illumination angles are required for different imaging depths to get the 
      highest SNR PA images. The results also validate that one can use Monte Carlo 
      simulation as a tool to optimize the probe holder design depending on the imaging 
      needs. This eliminates a trial-and-error approach generally used for designing a 
      probe holder.
FAU - Sivasubramanian, Kathyayini
AU  - Sivasubramanian K
AD  - Nanyang Technological University, School of Chemical and Biomedical Engineering, 
      62 Nanyang Drive, Singapore 637459, Singapore.
FAU - Periyasamy, Vijitha
AU  - Periyasamy V
AD  - Nanyang Technological University, School of Chemical and Biomedical Engineering, 
      62 Nanyang Drive, Singapore 637459, Singapore.
FAU - Wen, Kew Kok
AU  - Wen KK
AD  - Nanyang Technological University, School of Chemical and Biomedical Engineering, 
      62 Nanyang Drive, Singapore 637459, Singapore.
FAU - Pramanik, Manojit
AU  - Pramanik M
AD  - Nanyang Technological University, School of Chemical and Biomedical Engineering, 
      62 Nanyang Drive, Singapore 637459, Singapore.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - *Computer Simulation
MH  - Monte Carlo Method
MH  - Phantoms, Imaging
MH  - Photoacoustic Techniques/*methods
MH  - Reproducibility of Results
MH  - *Ultrasonics
EDAT- 2016/12/21 06:00
MHDA- 2018/07/04 06:00
CRDT- 2016/12/21 06:00
PHST- 2016/06/19 00:00 [received]
PHST- 2016/11/28 00:00 [accepted]
PHST- 2016/12/21 06:00 [entrez]
PHST- 2016/12/21 06:00 [pubmed]
PHST- 2018/07/04 06:00 [medline]
AID - 2594613 [pii]
AID - 10.1117/1.JBO.22.4.041008 [doi]
PST - ppublish
SO  - J Biomed Opt. 2017 Apr 1;22(4):41008. doi: 10.1117/1.JBO.22.4.041008.