PMID- 27997261 OWN - NLM STAT- MEDLINE DCOM- 20171016 LR - 20180816 IS - 1543-2742 (Electronic) IS - 1526-484X (Linking) VI - 27 IP - 3 DP - 2017 Jun TI - Effect of Exercise Intensity on Neurotrophic Factors and Blood-Brain Barrier Permeability Induced by Oxidative-Nitrosative Stress in Male College Students. PG - 239-246 LID - 10.1123/ijsnem.2016-0009 [doi] AB - We investigated the effects of aerobic exercise intensity on oxidative-nitrosative stress, neurotrophic factor expression, and blood-brain barrier (BBB) permeability. Fifteen healthy men performed treadmill running under low-intensity (LI), moderate-intensity (MI), and high-intensity (HI) conditions. Blood samples were collected immediately before exercise (IBE), immediately after exercise (IAE), and 60 min after exercise (60MAE) to examine oxidative-nitrosative stress (reactive oxygen species [ROS]; nitric oxide [NO]), neurotrophic factors (brain-derived neurotrophic factor [BDNF]; nerve growth factor [NGF]), and blood-brain barrier (BBB) permeability (S-100beta; neuron-specific enolase). ROS concentration significantly increased IAE and following HI (4.9 +/- 1.7 mM) compared with that after LI (2.8 +/- 1.4 mM) exercise (p < .05). At 60MAE, ROS concentration was higher following HI (2.5 +/- 1.2 mM) than after LI (1.5 +/- 0.5 mM) and MI (1.4 +/- 0.3 mM) conditions (p < .05). Plasma NO IAE increased significantly after MI and HI exercise (p < .05). Serum BDNF, NGF, and S-100b levels were significantly higher IAE following MI and HI exercise (p < .05). BDNF and S-100b were higher IAE following MI (29.6 +/- 3.4 ng/mL and 87.1 +/- 22.8 ng/L, respectively) and HI (31.4 +/- 3.8 ng/mL and 100.6 +/- 21.2 ng/L, respectively) than following LI (26.5 +/- 3.0 ng/mL and 64.8 +/- 19.2 ng/L, respectively) exercise (p < .05). 60MAE, S-100b was higher following HI (71.1 +/- 14.5 ng/L) than LI (56.2 +/- 14.7 ng/L) exercise (p < .05). NSE levels were not significantly different among all intensity conditions and time points (p > .05). Moderate- and/or high-intensity exercise may induce higher oxidative-nitrosative stress than may low-intensity exercise, which can increase peripheral neurotrophic factor levels by increasing BBB permeability. FAU - Roh, Hee-Tae AU - Roh HT FAU - Cho, Su-Youn AU - Cho SY FAU - Yoon, Hyung-Gi AU - Yoon HG FAU - So, Wi-Young AU - So WY LA - eng PT - Journal Article DEP - 20161220 PL - United States TA - Int J Sport Nutr Exerc Metab JT - International journal of sport nutrition and exercise metabolism JID - 100939812 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Reactive Oxygen Species) RN - 0 (S100 Calcium Binding Protein beta Subunit) RN - 0 (S100B protein, human) RN - 31C4KY9ESH (Nitric Oxide) RN - 7171WSG8A2 (BDNF protein, human) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - *Blood-Brain Barrier MH - Brain-Derived Neurotrophic Factor/*blood MH - Exercise/*physiology MH - Exercise Test MH - Humans MH - Male MH - Nerve Growth Factor/*blood MH - Nitric Oxide/blood MH - Oxidative Stress/*physiology MH - Reactive Oxygen Species/blood MH - Running/physiology MH - S100 Calcium Binding Protein beta Subunit/blood MH - Students MH - Young Adult OTO - NOTNLM OT - aerobic exercise OT - brain-derived neurotrophic factor OT - nitric oxide OT - reaction oxygen species EDAT- 2016/12/21 06:00 MHDA- 2017/10/17 06:00 CRDT- 2016/12/21 06:00 PHST- 2016/12/21 06:00 [pubmed] PHST- 2017/10/17 06:00 [medline] PHST- 2016/12/21 06:00 [entrez] AID - 10.1123/ijsnem.2016-0009 [doi] PST - ppublish SO - Int J Sport Nutr Exerc Metab. 2017 Jun;27(3):239-246. doi: 10.1123/ijsnem.2016-0009. Epub 2016 Dec 20.