PMID- 27997439
OWN - NLM
STAT- MEDLINE
DCOM- 20170809
LR  - 20170809
IS  - 1532-3145 (Electronic)
IS  - 0363-8715 (Linking)
VI  - 41
IP  - 4
DP  - 2017 Jul/Aug
TI  - Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients 
      With Hypertrophic Cardiomyopathy.
PG  - 653-660
LID - 10.1097/RCT.0000000000000564 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the structural and functional 
      correlates of T1 mapping in 321 patients with hypertrophic cardiomyopathy (HCM). 
      METHODS: Three hundred twenty-one patients with HCM who underwent cardiac 
      magnetic resonance from 2003 to 2013 were retrospectively identified from our 
      institution's HCM registry. Left ventricular volume, function, late gadolinium 
      enhancement (LGE), and Look-Locker T1 time were quantified. T1 time was 
      normalized to blood pool to calculate T1 ratio. Correlations between LGE%, T1 
      ratio, and structural and functional features were performed using Pearson 
      correlation coefficient. RESULTS: Late gadolinium enhancement showed stronger 
      correlation with left ventricular mass index (r = 0.41, P < 0.001) compared with 
      T1 ratio (r = -0.17, P = 0.004). Both LGE% and T1 ratio correlated with ejection 
      fraction (r = -0.18 and P = 0.002 vs r = 0.21 and P < 0.001, respectively). E/e' 
      showed correlation with LGE% but not with T1 ratio. CONCLUSIONS: Late gadolinium 
      enhancement was more strongly correlated with the phenotypic expression of HCM 
      compared with T1 ratio.
FAU - Chu, Linda C
AU  - Chu LC
AD  - From the *Russell H. Morgan Department of Radiology and Radiological Science, 
      Johns Hopkins University School of Medicine and Departments of daggerPathology and 
      double daggerCardiology, Johns Hopkins University School of Medicine, Baltimore, MD; 
       section signDivision of Image Processing, Department of Radiology, Leiden University Medical 
      Center, Leiden, The Netherlands; and  parallelRadiology and Imaging Sciences, Clinical 
      Center, National Institutes of Health, Bethesda, MD.
FAU - Corona-Villalobos, Celia P
AU  - Corona-Villalobos CP
FAU - Halushka, Marc K
AU  - Halushka MK
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Pozzessere, Chiara
AU  - Pozzessere C
FAU - Kamel, Ihab R
AU  - Kamel IR
FAU - Pozios, Iraklis
AU  - Pozios I
FAU - Van Der Geest, Rob J
AU  - Van Der Geest RJ
FAU - Gai, Neville
AU  - Gai N
FAU - Abraham, Roselle M
AU  - Abraham RM
FAU - Abraham, Theodore P
AU  - Abraham TP
FAU - Bluemke, David A
AU  - Bluemke DA
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Comput Assist Tomogr
JT  - Journal of computer assisted tomography
JID - 7703942
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - Child
MH  - *Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart/diagnostic imaging/physiopathology
MH  - Humans
MH  - *Image Enhancement
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2016/12/21 06:00
MHDA- 2017/08/10 06:00
CRDT- 2016/12/21 06:00
PHST- 2016/12/21 06:00 [pubmed]
PHST- 2017/08/10 06:00 [medline]
PHST- 2016/12/21 06:00 [entrez]
AID - 10.1097/RCT.0000000000000564 [doi]
PST - ppublish
SO  - J Comput Assist Tomogr. 2017 Jul/Aug;41(4):653-660. doi: 
      10.1097/RCT.0000000000000564.