PMID- 27998997
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20240405
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 12
IP  - 3
DP  - 2017 Mar 1
TI  - Differential functional connectivity of rostral anterior cingulate cortex during 
      emotional interference.
PG  - 476-486
LID - 10.1093/scan/nsw137 [doi]
AB  - The rostral-ventral subdivision of the anterior cingulate cortex (rACC) plays a 
      key role in the regulation of emotional processing. Although rACC has strong 
      anatomical connections with anterior insular cortex (AIC), amygdala, prefrontal 
      cortex and striatal brain regions, it is unclear whether the functional 
      connectivity of rACC with these regions changes when regulating emotional 
      processing. Furthermore, it is not known whether this connectivity changes with 
      deficits in emotion regulation seen in different kinds of anxiety and depression. 
      To address these questions regarding rACC functional connectivity, non-patients 
      high in self-reported anxious apprehension (AP), anxious arousal (AR), anhedonic 
      depression (AD) or none (CON) indicated the ink color of pleasant, neutral and 
      unpleasant words during functional magnetic resonance imaging. While ignoring 
      task-irrelevant unpleasant words, AD and CON showed an increase in the functional 
      connectivity of rACC with AIC, putamen, caudate and ventral pallidum. There was a 
      decrease in this connectivity in AP and AR, with AP showing greater reduction 
      than AR. These findings provide support for the role of rACC in integrating 
      interoceptive, emotional and cognitive functions via interactions with insula and 
      striatal regions during effective emotion regulation in healthy individuals and a 
      failure of this integration that may be specific to anxiety, particularly AP.
CI  - (c) The Author (2016). Published by Oxford University Press. For Permissions, 
      please email: journals.permissions@oup.com.
FAU - Szekely, Akos
AU  - Szekely A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY, USA.
FAU - Silton, Rebecca L
AU  - Silton RL
AD  - Department of Psychology, Loyola University, Chicago, IL, USA.
FAU - Heller, Wendy
AU  - Heller W
AD  - Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, 
      USA.
FAU - Miller, Gregory A
AU  - Miller GA
AD  - University of Illinois at Urbana-Champaign and University of California at Los 
      Angeles, Los Angeles, CA, USA.
AD  - Department of Psychology.
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California at 
      Los Angeles, Los Angeles, CA, USA.
FAU - Mohanty, Aprajita
AU  - Mohanty A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY, USA.
LA  - eng
GR  - T32 MH014257/MH/NIMH NIH HHS/United States
GR  - R01 MH061358/MH/NIMH NIH HHS/United States
GR  - P50 MH079485/MH/NIMH NIH HHS/United States
GR  - R21 DA014111/DA/NIDA NIH HHS/United States
GR  - T32 MH019554/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adolescent
MH  - Amygdala/physiopathology
MH  - Anxiety Disorders/physiopathology
MH  - Brain Mapping
MH  - Cerebral Cortex/physiopathology
MH  - Cognition/physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Young Adult
PMC - PMC5499751
OTO - NOTNLM
OT  - anxiety
OT  - cingulate
OT  - emotion
OT  - fMRI
OT  - functional connectivity
OT  - insula
EDAT- 2016/12/22 06:00
MHDA- 2017/10/17 06:00
PMCR- 2016/10/07
CRDT- 2016/12/22 06:00
PHST- 2015/11/23 00:00 [received]
PHST- 2016/09/21 00:00 [accepted]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
PHST- 2016/10/07 00:00 [pmc-release]
AID - nsw137 [pii]
AID - 10.1093/scan/nsw137 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2017 Mar 1;12(3):476-486. doi: 10.1093/scan/nsw137.