PMID- 27999414
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20240404
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 21
IP  - 12
DP  - 2016 Dec 20
TI  - Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for 
      Tumor Treatment.
LID - 10.3390/molecules21121715 [doi]
LID - 1715
AB  - Benefiting from the development of nanotechnology, drug delivery systems (DDSs) 
      with stimuli-responsive controlled release function show great potential in 
      clinical anti-tumor applications. By using a DDS, the harsh side effects of 
      traditional anti-cancer drug treatments and damage to normal tissues and organs 
      can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety 
      standards and secondarily the efficiency-related demands of a large drug payload 
      and controlled release function. This review highlights recent research progress 
      on DDSs with stimuli-responsive characteristics. The first section briefly 
      reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, 
      polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon 
      nanotubes (CNTs). The second section presents the main types of 
      stimuli-responsive mechanisms and classifies these into two categories: intrinsic 
      (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, 
      magnetic field and ultrasound) ones. Clinical applications of DDS, future 
      challenges and perspectives are also mentioned.
FAU - Ding, Chendi
AU  - Ding C
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China. salamicky@sina.cn.
FAU - Tong, Ling
AU  - Tong L
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China. njustlingtong321@sina.com.
FAU - Feng, Jing
AU  - Feng J
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China. fjnjust@163.com.
FAU - Fu, Jiajun
AU  - Fu J
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China. fujiajun668@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161220
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Polymers)
SB  - IM
MH  - Antineoplastic Agents/*chemistry
MH  - Drug Carriers/*chemistry
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Light
MH  - Magnetic Fields
MH  - Nanoparticles/chemistry
MH  - Nanotechnology
MH  - Nanotubes, Carbon/chemistry
MH  - Neoplasms/drug therapy
MH  - Oxidation-Reduction
MH  - Polymers/chemistry
MH  - Quantum Dots/chemistry
MH  - Temperature
MH  - Ultrasonics
PMC - PMC6273707
OTO - NOTNLM
OT  - anti-tumor treatment
OT  - drug delivery system
OT  - nanotechnology
OT  - stimuli response
COIS- The authors declare no conflict of interest.
EDAT- 2016/12/22 06:00
MHDA- 2017/03/10 06:00
PMCR- 2016/12/20
CRDT- 2016/12/22 06:00
PHST- 2016/09/15 00:00 [received]
PHST- 2016/11/26 00:00 [revised]
PHST- 2016/12/06 00:00 [accepted]
PHST- 2016/12/22 06:00 [entrez]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
PHST- 2016/12/20 00:00 [pmc-release]
AID - molecules21121715 [pii]
AID - molecules-21-01715 [pii]
AID - 10.3390/molecules21121715 [doi]
PST - epublish
SO  - Molecules. 2016 Dec 20;21(12):1715. doi: 10.3390/molecules21121715.