PMID- 28000002
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20191210
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 5
DP  - 2017 May
TI  - Stress perfusion magnetic resonance imaging to detect coronary artery lesions in 
      children.
PG  - 699-709
LID - 10.1007/s10554-016-1041-7 [doi]
AB  - BACKGROUND: Stress perfusion cardiovascular magnetic resonance (CMR) is used 
      widely in adult ischemic heart disease, but data in children is limited. We 
      sought to evaluate feasibility, accuracy and prognostic value of stress CMR in 
      children with suspected coronary artery disease (CAD). METHODS: Stress CMR was 
      reviewed from two pediatric centers over 5 years using a standard pharmacologic 
      protocol. Wall motion abnormalities, perfusion deficits and late enhancement were 
      correlated with coronary angiogram (CAG) when available, and clinical status at 
      1 year follow-up for major adverse cardiovascular events (MACE; coronary 
      revascularization, non-fatal myocardial infarction and death due to CAD) was 
      recorded. RESULTS: Sixty-four stress perfusion CMR studies in 48 children 
      (10.9 +/- 4.8 years) using adenosine; 59 (92%) and dipyridamole; 5 (8%), were 
      reviewed. Indications were Kawasaki disease (39%), post arterial switch operation 
      (12.5%), post heart transplantation (12.5%), post anomalous coronary artery 
      repair (11%), chest pain (11%), suspected myocarditis or CAD (3%), post coronary 
      revascularization (3%), and others (8%). Twenty-six studies were performed under 
      sedation. Of all studies performed, 66% showed no evidence of ischemia or 
      infarction, 28% had perfusion deficits and 6% had late gadolinium enhancement 
      (LGE) without perfusion deficit. Compared to CAG, the positive predictive value 
      (PPV) of stress CMR was 80% with negative predictive value (NPV) of 88%. At 
      1 year clinical follow-up, the PPV and NPV of stress CMR to predict MACE were 78 
      and 98%. CONCLUSION: Stress-perfusion CMR, in combination with LGE and wall 
      motion-analysis is a feasible and an accurate method of diagnosing CAD in 
      children. In difficult cases, it also helps guide clinical intervention by 
      complementing conventional CAG with functional information.
FAU - Vijarnsorn, Chodchanok
AU  - Vijarnsorn C
AD  - Stollery Children's Hospital and Mazankowski Alberta Heart Institute, University 
      of Alberta, Edmonton, Alberta, Canada. cvijarnsorn@yahoo.com.
AD  - Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand. cvijarnsorn@yahoo.com.
FAU - Noga, Michelle
AU  - Noga M
AD  - Stollery Children's Hospital and Mazankowski Alberta Heart Institute, University 
      of Alberta, Edmonton, Alberta, Canada.
FAU - Schantz, Daryl
AU  - Schantz D
AD  - Variety Children's Hospital, Winnipeg, Manitoba, Canada.
FAU - Pepelassis, Dion
AU  - Pepelassis D
AD  - Variety Children's Hospital, Winnipeg, Manitoba, Canada.
FAU - Tham, Edythe B
AU  - Tham EB
AD  - Stollery Children's Hospital and Mazankowski Alberta Heart Institute, University 
      of Alberta, Edmonton, Alberta, Canada.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20161220
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Alberta
MH  - Child
MH  - Contrast Media/administration & dosage
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*diagnostic imaging/mortality/physiopathology/therapy
MH  - *Coronary Circulation
MH  - Disease Progression
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Myocardial Infarction/diagnostic imaging/physiopathology
MH  - Myocardial Perfusion Imaging/*methods
MH  - Myocardial Revascularization
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Thailand
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Children
OT  - Stress myocardial perfusion imaging
EDAT- 2016/12/22 06:00
MHDA- 2017/10/03 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/08/26 00:00 [received]
PHST- 2016/12/08 00:00 [accepted]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
AID - 10.1007/s10554-016-1041-7 [pii]
AID - 10.1007/s10554-016-1041-7 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 May;33(5):699-709. doi: 10.1007/s10554-016-1041-7. 
      Epub 2016 Dec 20.