PMID- 28000476
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20181023
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 33
IP  - 6
DP  - 2016 Nov 29
TI  - Neuroprotective effect of Sapucaia nuts (Lecythis pisonis)on rats fed with 
      high-fat diet.
PG  - 1424-1429
LID - 10.20960/nh.805 [doi]
AB  - BACKGROUND: Lecythis pisonis Cambess is commonly known as "castanha de sapucaia" 
      in Brazil. Chemical composition studies revealed that this nut is an excellent 
      source of anti-oxidant minerals and of essential lipids. OBJECTIVE: The aim of 
      the present study is to assess the anti-oxidant and anti-inflammatory effect of 
      Lecythis pisonis Cambess on the brain tissue of Wistar rats. MATERIAL AND 
      METHODS: The animals were divided in four experimental groups (n = 6), total of 
      forty-eight rats. Treatments included the standard diet (AIN-93G) and high-fat 
      food, supplemented with Sapucaianut from 14 to 28 days. The gene expression 
      markers TNF-alpha, NFkB, ZnSOD and HSP-72 were defined through reverse transcriptase 
      polymerase chain reaction (rtPCR). The anti-oxidant effect was assessed through 
      the thiobarbituric acid-reactive substances (TBARS) and the measurement of the 
      activity performed by superoxide dismutase enzymes. RESULTS: Accordingly, the 
      gene expression of the inflammatory markers NFkB (p65) and TNF-alphawas lower in rats 
      fed on diets supplemented with "sapucaia", and they presented significant 
      difference in the Tukey test (p < 0.05). The heat-shock HSP-72 protein and the 
      ZnSOD enzyme raised the gene expression and showed significant statistical 
      difference (p < 0.05) in both groups fed on Sapucaia nut-based diet. CONCLUSION: 
      Thus, the nutritional properties of the Sapucaia nuts perform important 
      neuroprotective activities because they modulated the anti-oxidant activity and 
      the brain tissue inflammatory process in the assessed animals.
FAU - Vidal Martins, Marcos
AU  - Vidal Martins M
AD  - Departamento de Bioquimica e Biologia Molecular. Universidade Federal de Vicosa. 
      Universidade Federal do Oeste da Bahia, Campus Barreiras. 
      marcosvidalmartins@yahoo.com.br.
FAU - Montezano de Carvalho, Izabela Maria
AU  - Montezano de Carvalho IM
FAU - Magalhaes Caetano, Monica Maria
AU  - Magalhaes Caetano MM
FAU - Lopes Toledo, Renata Celi
AU  - Lopes Toledo RC
FAU - Avelar Xavier, Antonio
AU  - Avelar Xavier A
FAU - De Queiroz, Jose Humberto
AU  - De Queiroz JH
LA  - eng
PT  - Journal Article
DEP - 20161129
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
RN  - 0 (Antioxidants)
RN  - 0 (Dietary Fats)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Bertholletia/*chemistry
MH  - Brain Chemistry/drug effects
MH  - Dietary Fats/*adverse effects
MH  - Inflammation/prevention & control
MH  - Lecythidaceae/*chemistry
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Brain tissue. Oxidative stress. Inflammation. Gene expression.
EDAT- 2016/12/22 06:00
MHDA- 2017/10/24 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/11/29 00:00 [received]
PHST- 2016/12/22 06:00 [entrez]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
AID - 10.20960/nh.805 [doi]
PST - epublish
SO  - Nutr Hosp. 2016 Nov 29;33(6):1424-1429. doi: 10.20960/nh.805.