PMID- 28000518
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20210915
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 39
IP  - 1
DP  - 2017 Feb
TI  - Artemisinin inhibits inflammatory response via regulating NF-kappaB and MAPK 
      signaling pathways.
PG  - 28-36
LID - 10.1080/08923973.2016.1267744 [doi]
AB  - Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for 
      many years to treat different forms of malarial parasites. In this study, we 
      explored the anti-inflammatory activity of artemisinin and the underlying 
      mechanism of this action. We demonstrated that the anti-inflammatory effects of 
      artemisinin in TPA-induced skin inflammation in mice. Then the artemisinin 
      significantly inhibited the expression of NF-kappaB reporter gene induced by TNF-alpha in 
      a dose-dependent manner. Artemisinin also inhibited TNF-alpha induced phosphorylation 
      and degradation of IkappaBalpha, p65 nuclear translocation. Artemisinin also has an 
      impact on upstream signaling of IKK through the inhibition of expression of 
      adaptor proteins, TNF receptor-associated factor 2 (TRAF2) and receptor 
      interacting protein 1 (RIP1). Furthermore, pretreatment of cells with artemisinin 
      prevented the TNF-alpha-induced expression of NF-kappaB target genes, such as 
      anti-apoptosis (c-IAP1, Bcl-2, and FLIP), proliferation (COX-2, cyclinD1), 
      invasion (MMP-9), angiogenesis (VEGF), and major inflammatory cytokines (TNF-alpha, 
      iNOS, and MCP1). We also proved that artemisinin potentiated TNF-alpha-induced 
      apoptosis. Moreover, artemisinin significantly impaired the ROS production and 
      phosphorylation of p38 and ERK, but did not affect the phosphorylation of JNK. 
      Taken together, artemisinin may be a potentially useful therapeutic agent for 
      inflammatory-related diseases.
FAU - Wang, Ke Si
AU  - Wang KS
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Li, Junbo
AU  - Li J
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Wang, Zhe
AU  - Wang Z
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Mi, Chunliu
AU  - Mi C
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Ma, Juan
AU  - Ma J
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Piao, Lian Xun
AU  - Piao LX
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Xu, Guang Hua
AU  - Xu GH
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Li, Xuezheng
AU  - Li X
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
FAU - Jin, Xuejun
AU  - Jin X
AD  - a Key Laboratory of Natural Resources of Changbai Mountain & Functional 
      Molecules, Ministry of Education, Molecular Cancer Research Center, College of 
      Pharmacy , Yanbian University , Yanji, Jilin Province , China.
LA  - eng
PT  - Journal Article
DEP - 20161221
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (AGFG1 protein, human)
RN  - 0 (Artemisinins)
RN  - 0 (NF-kappa B)
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (TNF Receptor-Associated Factor 1)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9RMU91N5K2 (artemisinin)
SB  - IM
MH  - Animals
MH  - Artemisinins/*pharmacology
MH  - Cell Line
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects/immunology
MH  - Humans
MH  - Inflammation/chemically induced/drug therapy/immunology
MH  - MAP Kinase Signaling System/*drug effects/immunology
MH  - Mice
MH  - NF-kappa B/*immunology
MH  - Nuclear Pore Complex Proteins/immunology
MH  - RNA-Binding Proteins/immunology
MH  - TNF Receptor-Associated Factor 1/immunology
MH  - TNF Receptor-Associated Factor 2/immunology
MH  - Tumor Necrosis Factor-alpha/adverse effects/pharmacology
OTO - NOTNLM
OT  - Artemisinin
OT  - Inflammation
OT  - IkappaBalpha
OT  - MAPK
OT  - Nuclear factor-kappaB (NF-kappaB)
EDAT- 2016/12/22 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
AID - 10.1080/08923973.2016.1267744 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2017 Feb;39(1):28-36. doi: 
      10.1080/08923973.2016.1267744. Epub 2016 Dec 21.