PMID- 28001185
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20220408
IS  - 2175-8239 (Electronic)
IS  - 0101-2800 (Linking)
VI  - 38
IP  - 4
DP  - 2016 Dec
TI  - Serum uric acid and its association with hypertension, early nephropathy and 
      chronic kidney disease in type 2 diabetic patients.
PG  - 403-410
LID - S0101-28002016000400403 [pii]
LID - 10.5935/0101-2800.20160065 [doi]
AB  - INTRODUCTION: Early detection diabetic nephropathy (DN) is important. Whether 
      serum uric acid (SUA) has a role in the development of DN is not known. 
      OBJECTIVE: To study the relationship between SUA and hypertension, early 
      nephropathy and progression of chronic kidney disease (CKD) in type 2 diabetes 
      mellitus (T2DM). METHODS: The total number of the study was 986 participants, 
      according to presence and duration of diabetes were classified into three groups. 
      Group I; including 250 healthy participants. Group II; including 352 with onset 
      of diabetes < 5 years. Group III; including 384, with the onset of diabetes > 5 
      years. All participants were submitted to complete clinical examination, 
      anthropometric measurements, laboratory investigations, including glycosylated 
      hemoglobin (HbA1C), as well triglycerides to high-density lipoprotein ratios 
      (TG/HDL-C), SUA, urinary albumin/creatinine ratio (ACR) and estimated glomerular 
      filtration rate (eGFR). RESULTS: SUA, BP, HbA1c, TG/HDL-C ratio, and ACR levels 
      were significantly higher in group III than group I, II and in II than I. eGFR 
      significantly lower in group III than group I, II and in II than I (p < 0.001). 
      Age, BMI, BP, HbA1c, TG/HDL-C, ACR, were positively correlated with SUA, while 
      GFR negatively correlated. SUA at level of > 6.1 mg/dl, > 6.2 mg/dl and > 6.5 
      mg/dl had a greater sensitivity and specificity for identifying hypertension, 
      early nephropathy and decline eGFR respectively. CONCLUSION: Even high normal SUA 
      level, was associated with the risk of hypertension, early nephropathy and 
      decline of eGFR. Moreover SUA level may identify the onset of hypertension, early 
      nephropathy and progression of CKD in T2DM.
FAU - Fouad, Mohamed
AU  - Fouad M
AD  - Department of Nepherology, Zagazig University Hospital, Zagazig, Egypt.
FAU - Fathy, Hoda
AU  - Fathy H
AD  - Departments of Clinical Pathology, Zagazig University Hospital, Zagazig, Egypt.
FAU - Zidan, Amal
AU  - Zidan A
AD  - Departments of Clinical Pathology, Zagazig University Hospital, Zagazig, Egypt.
LA  - por
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - J Bras Nefrol
JT  - Jornal brasileiro de nefrologia
JID - 9426946
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Nephropathies/*blood/*etiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/*etiology
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/*blood/*etiology
MH  - Time Factors
MH  - Uric Acid/*blood
EDAT- 2016/12/22 06:00
MHDA- 2018/01/30 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/04/11 00:00 [received]
PHST- 2016/08/09 00:00 [accepted]
PHST- 2016/12/22 06:00 [entrez]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
AID - S0101-28002016000400403 [pii]
AID - 10.5935/0101-2800.20160065 [doi]
PST - ppublish
SO  - J Bras Nefrol. 2016 Dec;38(4):403-410. doi: 10.5935/0101-2800.20160065.