PMID- 28002024
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20211204
IS  - 1437-4315 (Electronic)
IS  - 1431-6730 (Linking)
VI  - 398
IP  - 7
DP  - 2017 Jun 27
TI  - The cancer cell adhesion resistome: mechanisms, targeting and translational 
      approaches.
PG  - 721-735
LID - 10.1515/hsz-2016-0326 [doi]
AB  - Cell adhesion-mediated resistance limits the success of cancer therapies and is a 
      great obstacle to overcome in the clinic. Since the 1990s, where it became clear 
      that adhesion of tumor cells to the extracellular matrix is an important mediator 
      of therapy resistance, a lot of work has been conducted to understand the 
      fundamental underlying mechanisms and two paradigms were deduced: cell 
      adhesion-mediated radioresistance (CAM-RR) and cell adhesion-mediated drug 
      resistance (CAM-DR). Preclinical work has evidently demonstrated that targeting 
      of integrins, adapter proteins and associated kinases comprising the cell 
      adhesion resistome is a promising strategy to sensitize cancer cells to both 
      radiotherapy and chemotherapy. Moreover, the cell adhesion resistome 
      fundamentally contributes to adaptation mechanisms induced by radiochemotherapy 
      as well as molecular drugs to secure a balanced homeostasis of cancer cells for 
      survival and growth. Intriguingly, this phenomenon provides a basis for synthetic 
      lethal targeted therapies simultaneously administered to standard 
      radiochemotherapy. In this review, we summarize current knowledge about the cell 
      adhesion resistome and highlight targeting strategies to override CAM-RR and 
      CAM-DR.
FAU - Dickreuter, Ellen
AU  - Dickreuter E
AD  - , Faculty of Medicine and University Hospital Carl Gustav Carus.
FAU - Cordes, Nils
AU  - Cordes N
AD  - , Faculty of Medicine and University Hospital Carl Gustav Carus.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Biol Chem
JT  - Biological chemistry
JID - 9700112
SB  - IM
MH  - Animals
MH  - Cell Adhesion/*drug effects
MH  - Drug Resistance, Neoplasm/*drug effects
MH  - Humans
MH  - Molecular Targeted Therapy/*methods
MH  - Neoplasms/*drug therapy/metabolism/*pathology
MH  - Translational Research, Biomedical/*methods
OTO - NOTNLM
OT  - CAM-DR
OT  - CAM-RR
OT  - EGFR
OT  - adhesion
OT  - integrin
OT  - resistome
EDAT- 2016/12/22 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2016/12/12 00:00 [accepted]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
AID - /j/bchm.just-accepted/hsz-2016-0326/hsz-2016-0326.xml [pii]
AID - 10.1515/hsz-2016-0326 [doi]
PST - ppublish
SO  - Biol Chem. 2017 Jun 27;398(7):721-735. doi: 10.1515/hsz-2016-0326.