PMID- 28002270
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20220408
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 37
IP  - 9
DP  - 2017 Sep
TI  - OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH BEHCET UVEITIS.
PG  - 1678-1691
LID - 10.1097/IAE.0000000000001418 [doi]
AB  - PURPOSE: To describe optical coherence tomography angiography (OCTA) findings in 
      eyes with Behcet uveitis (BU) and to compare these findings with those of 
      fluorescein angiography (FA). METHODS: Prospective, comparative, cross-sectional 
      study. Patients presenting with clinically active BU involving the posterior 
      segment were evaluated using FA, spectral domain optical coherence tomography 
      (SD-OCT), and OCTA. Optical coherence tomography angiograms were reviewed and 
      analyzed. Foveal avascular zone areas and vessel densities were also reported. 
      RESULTS: Twenty-five patients (44 eyes) were included. Perifoveal microvascular 
      changes were more frequently observed on OCTA than on FA (95.5 vs 59.1%; P < 
      0.001). Disruption of the perifoveal capillary arcade, areas of retinal capillary 
      nonperfusion/hypoperfusion, and perifoveal capillary abnormalities, including 
      rarefied, dilated, or shunting vessels were observed more frequently using OCTA 
      than FA (40.9 vs 25%; P = 0.039, 86.4 vs 34.1%; P < 0.001, and 84.1 vs 36.4%; P < 
      0.001, respectively). Areas of retinal capillary nonperfusion/hypoperfusion were 
      more frequently observed in the deep than in the superficial capillary plexus 
      (81.8 vs 63.6%; P = 0.039). Capillary abnormalities and disorganization of the 
      normal architecture of the capillary network were more frequent in the deep than 
      in the superficial capillary plexus (P < 0.001). Foveal avascular zone area was 
      not significantly larger in eyes with BU than in control group in both the 
      superficial and the deep capillary plexuses (0.4 vs 0.34 mm; P = 0.23 and 0.72 vs 
      0.53 mm; P = 0.053, respectively). Capillary vessel density was significantly 
      lower in eyes with BU than in control group in the deep capillary plexus (13.7 vs 
      17.2 mm 21; P = 0.004). CONCLUSION: OCTA allows better visualization and 
      characterization of perifoveal microvascular changes than FA in eyes with active 
      BU. The deep capillary plexus seemed to be more severely involved than the 
      superficial capillary plexus.
FAU - Khairallah, Moncef
AU  - Khairallah M
AD  - *Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of 
      Medicine, University of Monastir, Monastir, Tunisia; daggerDepartment of 
      Ophthalmology, Creteil Hospital, University of Paris Est, Creteil, France; and 
      double daggerOdeon Ophthalmological Center, Paris, France.
FAU - Abroug, Nesrine
AU  - Abroug N
FAU - Khochtali, Sana
AU  - Khochtali S
FAU - Mahmoud, Anis
AU  - Mahmoud A
FAU - Jelliti, Bechir
AU  - Jelliti B
FAU - Coscas, Gabriel
AU  - Coscas G
FAU - Lupidi, Marco
AU  - Lupidi M
FAU - Kahloun, Rim
AU  - Kahloun R
FAU - Ben Yahia, Salim
AU  - Ben Yahia S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Microvessels/diagnostic imaging/pathology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Vessels/diagnostic imaging/pathology
MH  - *Tomography, Optical Coherence
MH  - Uveitis/diagnostic imaging/*pathology
MH  - Young Adult
EDAT- 2016/12/22 06:00
MHDA- 2018/01/10 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
AID - 10.1097/IAE.0000000000001418 [doi]
PST - ppublish
SO  - Retina. 2017 Sep;37(9):1678-1691. doi: 10.1097/IAE.0000000000001418.