PMID- 28004271
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20190723
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 57
IP  - 2
DP  - 2018 Mar
TI  - Maternal vitamin D deficiency during pregnancy affects expression of 
      adipogenic-regulating genes peroxisome proliferator-activated receptor gamma 
      (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring.
PG  - 723-730
LID - 10.1007/s00394-016-1359-x [doi]
AB  - PURPOSE: Maternal vitamin D deficiency during pregnancy is a widespread issue 
      that may have long-lasting consequences on offspring adiposity. We sought to 
      determine how maternal vitamin D deficiency during the perinatal period would 
      affect offspring adipose tissue development and gene expression. METHODS: Female 
      C57BL/6 J mice were fed either a vitamin D deficient (VDD) or control diet from 
      4 weeks before pregnancy (periconception) until 7 days postparturition. Male 
      offspring were weighed and euthanized at 75 days of age (early adult period), at 
      which point serum was collected for biochemical analyses, and perigonadal and 
      subcutaneous white adipose tissue (PGAT and SQAT, respectively) were excised, 
      weighed, then flash-frozen for later histology and analyses of adipogenic gene 
      expression. RESULTS: All adult male offspring were nonobese; there were no 
      significant differences in body weight, adipose pad weight, or adipocyte size. 
      However, VDD-exposed offspring had greater expression of the 
      adipogenic-regulating genes peroxisome proliferator-activated receptor gamma 
      (Pparg) and vitamin D receptor (Vdr). CONCLUSIONS: This study suggests that 
      exposure to vitamin D deficiency during the perinatal period can directly affect 
      genes involved in the development of adipose tissue in nonobese offspring. These 
      novel findings invite further investigation into the mechanisms by which maternal 
      vitamin D status during pregnancy affects adipose development and metabolic 
      health of offspring.
FAU - Belenchia, Anthony M
AU  - Belenchia AM
AD  - Department of Nutrition and Exercise Physiology, University of Missouri, 204 
      Gwynn Hall, Columbia, MO, 65211, USA.
FAU - Jones, Karen L
AU  - Jones KL
AD  - MIND Institute, University of California, Davis, 2825 50th St, Sacramento, CA, 
      95817, USA.
AD  - Division of Rheumatology, Allergy, and Clinical Immunology, Department of 
      Internal Medicine, University of California-Davis, Davis, CA, USA.
FAU - Will, Matthew
AU  - Will M
AD  - Bond Life Sciences Center, University of Missouri, 1201 Rollins St, Columbia, MO, 
      65201, USA.
AD  - Department of Psychological Sciences, University of Missouri, 1020 Hitt Street, 
      Columbia, MO, 65212-0001, USA.
FAU - Beversdorf, David Q
AU  - Beversdorf DQ
AD  - Thompson Autism Center for Neurodevelopmental Disorders, University of Missouri, 
      205 Portland St, Columbia, MO, 65201-6521, USA.
FAU - Vieira-Potter, Victoria
AU  - Vieira-Potter V
AD  - Department of Nutrition and Exercise Physiology, University of Missouri, 204 
      Gwynn Hall, Columbia, MO, 65211, USA.
FAU - Rosenfeld, Cheryl S
AU  - Rosenfeld CS
AD  - Bond Life Sciences Center, University of Missouri, 1201 Rollins St, Columbia, MO, 
      65201, USA.
AD  - Department Biomedical Sciences, University of Missouri, 440F Life Sciences 
      Center, Columbia, MO, 65211, USA.
FAU - Peterson, Catherine A
AU  - Peterson CA
AD  - Department of Nutrition and Exercise Physiology, University of Missouri, 204 
      Gwynn Hall, Columbia, MO, 65211, USA. petersonca@missouri.edu.
LA  - eng
GR  - RC1 ES018195/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20161221
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Adipokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (PPAR gamma)
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Adipokines/blood/metabolism
MH  - Adipose Tissue, White/immunology/*metabolism/pathology
MH  - Adiposity
MH  - Animals
MH  - Cell Size
MH  - Female
MH  - Fetal Development
MH  - *Gene Expression Regulation, Developmental
MH  - Inflammation Mediators/blood/metabolism
MH  - Lactation
MH  - Male
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Mice, Inbred C57BL
MH  - PPAR gamma/genetics/*metabolism
MH  - Panniculitis/*etiology/immunology/metabolism/pathology
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy Complications/physiopathology
MH  - Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Receptors, Calcitriol/genetics/*metabolism
MH  - Vitamin D Deficiency/*physiopathology
PMC - PMC6643277
MID - NIHMS1041916
OTO - NOTNLM
OT  - Adipogenesis
OT  - DOHaD
OT  - Fetal programming
OT  - Gene expression
OT  - Pregnancy
OT  - Vitamin D
COIS- Conflicts of interest All authors declare that they have no conflicts of 
      interest.
EDAT- 2016/12/23 06:00
MHDA- 2018/09/05 06:00
PMCR- 2019/07/22
CRDT- 2016/12/23 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2016/12/06 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2016/12/23 06:00 [entrez]
PHST- 2019/07/22 00:00 [pmc-release]
AID - 10.1007/s00394-016-1359-x [pii]
AID - 10.1007/s00394-016-1359-x [doi]
PST - ppublish
SO  - Eur J Nutr. 2018 Mar;57(2):723-730. doi: 10.1007/s00394-016-1359-x. Epub 2016 Dec 
      21.