PMID- 28004791
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20220331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Dec 22
TI  - Free Triiodothyronine Level Correlates with Myocardial Injury and Prognosis in 
      Idiopathic Dilated Cardiomyopathy: Evidence from Cardiac MRI and SPECT/PET 
      Imaging.
PG  - 39811
LID - 10.1038/srep39811 [doi]
LID - 39811
AB  - Thyroid dysfunction is associated with poor prognosis in heart failure, but 
      theories of mechanisms are mainly based on animal experiments, not on human 
      level. We aimed to explore the relation between thyroid function and myocardial 
      injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic 
      resonance imaging (MRI), single-photon emission computed tomography (SPECT) and 
      positron emission tomography (PET). Myocardial fibrosis was detected by late 
      gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was 
      evaluated by (99m)Tc-MIBI SPECT /(18)F-FDG PET imaging. Across the quartiles of 
      FT3, decreased percentage of segments with LGE and perfusion/metabolism 
      abnormalities were found. As for FT4 and TSH levels, no significant distribution 
      trend of myocardial injuries could be detected. In logistic analysis, FT3 was 
      independently associated with the presence of LGE (OR: 0.140, 95% CI: 
      0.035-0.567), perfusion abnormalities (OR: 0.172, 95% CI: 0.040-0.738) and 
      metabolism abnormalities (OR: 0.281, 95% CI: 0.081-0.971). After a median 
      follow-up of 46 months, LGE-positive and FT3 < 2.77 pg/mL was identified as the 
      strongest predictor of cardiac events (HR: 8.623, 95% CI: 3.626-16.438). Low FT3 
      level is associated with myocardial fibrosis and perfusion/metabolism 
      abnormalities in patients with IDCM. The combination of FT3 level and LGE 
      provides useful information for assessing the prognosis of IDCM.
FAU - Wang, Wenyao
AU  - Wang W
AD  - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, China.
FAU - Guan, Haixia
AU  - Guan H
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      China Medical University, Shenyang, China.
FAU - Fang, Wei
AU  - Fang W
AD  - Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, 
      Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Zhang, Kuo
AU  - Zhang K
AD  - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, China.
FAU - Gerdes, A Martin
AU  - Gerdes AM
AD  - Department of Biomedical Sciences, New York Institute of Technology-College of 
      Osteopathic Medicine, Old Westbury, New York, USA.
FAU - Iervasi, Giorgio
AU  - Iervasi G
AD  - Clinical Physiology Institute, Consiglio Nazionale delle Ricerche (CNR), Pisa, 
      Italy.
FAU - Tang, Yi-Da
AU  - Tang YD
AD  - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20161222
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Contrast Media)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - *Cardiomyopathy, Dilated/blood/diagnostic imaging
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium/administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Myocardium
MH  - *Positron-Emission Tomography
MH  - Prognosis
MH  - Prospective Studies
MH  - Triiodothyronine/*blood
PMC - PMC5177909
EDAT- 2016/12/23 06:00
MHDA- 2018/07/10 06:00
PMCR- 2016/12/22
CRDT- 2016/12/23 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/12/23 06:00 [entrez]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2016/12/22 00:00 [pmc-release]
AID - srep39811 [pii]
AID - 10.1038/srep39811 [doi]
PST - epublish
SO  - Sci Rep. 2016 Dec 22;6:39811. doi: 10.1038/srep39811.