PMID- 28005218
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 5
DP  - 2017 May
TI  - Impact of surgical pulmonary valve replacement on ventricular mechanics in 
      children with repaired tetralogy of Fallot.
PG  - 711-720
LID - 10.1007/s10554-016-1046-2 [doi]
AB  - Impaired ventricular myocardial mechanics are observed in patients with repaired 
      tetralogy of Fallot (rTOF). Effects of pulmonary valve replacement (PVR) on 
      ventricular remodeling are controversial. The objective was to assess the impact 
      of surgical PVR on ventricular mechanics in pediatric patients after rTOF. 
      Speckle-tracking analysis was performed in 50 rTOF children, aged 
      12.6 +/- 3.3 years, pre-operatively and 14.5 +/- 2.2 months post-PVR. Early 
      post-operative studies 2.2 +/- 0.6 months post-PVR were performed in 28 patients. 
      Cardiac magnetic resonance (CMR) pre- and post-PVR was collected. Mid-term 
      post-PVR right ventricular (RV) longitudinal strain increased above pre-operative 
      strain (-19.2 +/- 2.7 to -22.0 +/- 3.0%, p < 0.001) with increases observed in 
      individual RV segments. Left ventricular (LV) strain did not differ at 
      medium-term follow-up. LV and RV longitudinal strain was reduced early 
      post-operatively, followed by recovery of biventricular systolic strain by 
      mid-term follow-up. CMR RV end-diastolic indexed volumes correlated with RV 
      strain pre-operatively (r = 0.432, p = 0.005) and at mid-term follow-up 
      (r = 0.532, p = 0.001). Volume-loaded RVs had reduced early RV basal longitudinal 
      strain compared to pressure-loading conditions. Reversed basal counterclockwise 
      rotation was associated with lower mid-term global LV and basal RV strain 
      compared to patients with normal rotation. An increase in mid-term global and 
      regional RV strain beyond pre-operative values suggests positive RV remodeling 
      and adaptation occurs in children post-PVR. Patients with larger pre-operative RV 
      volumes had lower RV strain post-operatively. The impact of LV rotation on RV 
      mechanics highlights the presence of ventriculo-ventricular interactions. These 
      findings have important clinical implications in pediatric rTOF patients towards 
      identifying pre-operative factors that predict RV post-operative remodeling.
FAU - Yim, D
AU  - Yim D
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
FAU - Mertens, L
AU  - Mertens L
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
FAU - Morgan, C T
AU  - Morgan CT
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
FAU - Friedberg, M K
AU  - Friedberg MK
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
FAU - Grosse-Wortmann, L
AU  - Grosse-Wortmann L
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
FAU - Dragulescu, A
AU  - Dragulescu A
AD  - The Labatt Family Heart Centre, The Hospital for Sick Children, University of 
      Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. 
      andreea.dragulescu@sickkids.ca.
LA  - eng
PT  - Journal Article
DEP - 20161222
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Adaptation, Physiological
MH  - Adolescent
MH  - Biomechanical Phenomena
MH  - *Cardiac Surgical Procedures/adverse effects
MH  - Child
MH  - Cross-Sectional Studies
MH  - Echocardiography
MH  - Female
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Myocardial Contraction
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Pulmonary Valve/diagnostic imaging/physiopathology/*surgery
MH  - Pulmonary Valve Insufficiency/diagnostic 
      imaging/etiology/physiopathology/*surgery
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Stress, Mechanical
MH  - Tetralogy of Fallot/physiopathology/*surgery
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
MH  - *Ventricular Function, Right
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - Myocardial deformation
OT  - PVR
OT  - Pulmonary valve replacement
OT  - Strain
OT  - TOF
OT  - Tetralogy of Fallot
EDAT- 2016/12/23 06:00
MHDA- 2017/10/03 06:00
CRDT- 2016/12/23 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2016/12/23 06:00 [entrez]
AID - 10.1007/s10554-016-1046-2 [pii]
AID - 10.1007/s10554-016-1046-2 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 May;33(5):711-720. doi: 10.1007/s10554-016-1046-2. 
      Epub 2016 Dec 22.